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Articles by D. Kannan
Total Records ( 3 ) for D. Kannan
  P. Thirunavukkarasu , T. Ramanathan , S. Asha , V. Manigandan and D. Kannan
  Rhizophora apiculata, a mangrove specie is used in traditional medicine against several human diseases including tumor. To validate the ethnopharmacological claims against cancer, we examined the effects of Rhizophora apiculata leaf oil on the anti gastric cancer activities of Benzo(a)pyrene (BaP) induced gastric cancer in albino mice. The animals were divided into five groups. Group I were given BaP (40 mg kg-1 b.wt.) with 100 μL sesame oil by oral gavage twice a week for 4 consecutive weeks. Group II were given 100 μL sesame oil (SMO) treated (Vehicle treated control) a week for 4 consecutive weeks. Group III mice (BaP) (40 mg kg-1 b.wt.)+R. apiculata (50 μL) for 14 weeks. Group IV only R. apiculata (50 μL kg-1 b.wt.) dialy for two weeks. Goup V as the control non treated. At end of 14 weeks, all the animal were killed. Tumor incidence was observed to be 100% in mice that received only BaP. However, treatment with R. apiculata oil reduced the tumor incidence as observed in mice of BaP+R. apiculata oil group when compared to that of BaP group. Similarly, the tumor burden and body weight were seen to decrease by 137.21, respectively in mice of BaP+R. apiculata oil group when compared to those of BaP group. Diminished lipid peroxidation in the stomach tumor tissue was associated with enhanced antioxidant levels. In contrast to tumor tissue, enhanced lipid peroxidation with compromised antioxidant defences was found in the liver and erythrocytes of tumor bearing animals. Administration of R. apiculata oil significantly reduced the incidence of stomach tumors, modulated lipid peroxidation and enhanced antioxidant status in the stomach, liver and blood. From the results of our study, we suggest that R. apiculata oil may exert its chemopreventive effects by modulating lipid peroxidation and enhancing the antioxidant status in the stomach, liver and erythrocytes.
  D. Kannan , K. Jagadeesan , N. Shettu , A. Gopalakrishnan and P. Thirunavukkarasu
  A quantitative study was made on the occurrence of cholesterol in the muscle of different maturity stages of the wilder tiger shrimp Penaeus monodon collected from Pazhayar coast, Nagapattinam, Tamil Nadu. As the size increased from 8-10 cm to 14-16 cm the cholesterol content increased from 1.4-4.5 mg g-1. The shrimp contained almost the same level of cholesterol in both sexes. The variation in the cholesterol level in relation to moulting in the male and female shrimp revealed that in both the sexes high cholesterol content was noticed in the intermoult stage. Subsequently, in the premoult stage the cholesterol content decreased from 2.0-1.8 mg g-1 and it was found to be the lowest among all the moult stages. In the matured stages the shrimp contained higher level of cholesterol (2.1 mg g-1) and very less amount of cholesterol level (1.2 mg g-1) in the immature and early mature stages. It is inferred from this study that the cholesterol level was more in the intermoult stage suggesting that cholesterol may be converted to some moulting hormones.
  D. Kannan , K. Jagadeesan , N. Shettu and P. Thirunavukkarasu
  The Penaeid shrimp commonly known as tiger shrimp is commercially important candidate species for brackish water aquaculture in India. The spawning seasons of penaeid shrimp, P. monodon from Pazhayar coast were studied on the basis of ovarian colour. During maturation shrimp ovaries pass through a series of colour changes. Females with olive green i.e., black green with butterfly band shaped ovaries considered as fully ripening one which is ready to spawn. The presence of fully ripened ovaries of P. monodon throughout the year suggests that these shrimp have the potential for spawning all the twelve months in a year. However, P. monodon noticed with two spawning peaks viz., March and August. Among these two seasons, the highest number of stages with maturity was noticed in the month of March.
 
 
 
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