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Articles by D. Kang
Total Records ( 2 ) for D. Kang
  J. Y Lee , A. K Park , K. M Lee , S. K Park , S Han , W Han , D. Y Noh , K. Y Yoo , H Kim , S. J Chanock , N Rothman and D. Kang

Objectives: This study was conducted to investigate the role of common variation in innate immunity-related genes as susceptibility factors to breast cancer risk in Korean women. Methods: Total 1536 single-nucleotide polymorphisms (SNPs) in 203 genes were analyzed by Illumina GoldenGate assay in 209 cases and the same numbers of controls. Both SNP and gene-based tests were used to evaluate the association with breast cancer risk. The robustness of results was further evaluated with permutation method, false discovery rate and haplotype analyses. Results: Both SNP and gene-based analyses showed promising associations with breast cancer risk for 17 genes: OR10J3, FCER1A, NCF4, CNTNAP1, CTNNB1, KLKB1, ITGB2, ALOX12B, KLK2, IRAK3, KLK4, STAT6, NCF2, CCL1, C1QR1, MBP and NOS1. The most significant association with breast cancer risk was observed for the OR10J3 SNP (rs2494251, P-value = 1.2 x 10–4) and FCER1A SNP (rs7548864, P-value = 7.7 x 10–4). Gene-based permutation and false discovery rate P-values for OR10J3 SNP (rs2494251) with breast cancer risk were also significant (P = 4 x 10–5 and 0.008, respectively). Haplotype analyses supported these findings that OR10J3 and FCER1A were most significantly associated with risk for breast cancer (P = 2 x 10–4 and 0.004, respectively). Conclusion: This study suggests that common genetic variants in the OR10J3 and FCER1A be strongly associated with breast cancer risk among Korean women.

  T. H Bok , D. G Paeng , E Kim , J Na and D. Kang

The acoustic integrated backscattered power (IBP) of the phytoplankton Cochlodinium polykrikoides, which causes red tides in Korean waters, was measured in the laboratory and in the sea in situ to investigate the feasibility of observing red tides using high frequency ultrasound at 5 and 10 MHz. The IBP was measured with cultured C. polykrikoides at abundance levels of 90, 110, 200, 260, 300, 340, 360, 600, 700 and 850 cells/mL in the laboratory. Using the same high frequency acoustic transducers that were attached to the side of a research vessel, the IBP was measured in situ over a 9 km ship track near the Gumo Islands in Yeosu in the Southern Sea of Korea during the red tide season. The IBP was also measured simultaneously with positional information obtained from global positioning system data and by sampling the seawater in which C. polykrikoides was counted to survey the C. polykrikoides distribution in the study area. The IBP in situ was in agreement with that in the laboratory depending on the C. polykrikoides abundance. Consequently, we suggest that it is feasible to use underwater ultrasonic methodology for the observation of red tides in real time in situ.

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