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Articles by D. Giordano
Total Records ( 3 ) for D. Giordano
  R. D`Anna , G. Baviera , F. Corrado , D. Giordano , S. Recupero and A. Di Benedetto
  Aims: Neutrophil gelatinase-associated lipocalin (NGAL) is highly expressed in damaged epithelia, during inflammation and cardiovascular disease. Soluble NGAL was measured in women who subsequently developed gestational diabetes.
Methods: From a cohort of 908 pregnant outpatients who participated in a screening programme for Down's syndrome at 9–12 weeks of gestation, we considered all 41 women with a singleton pregnancy, who developed gestational diabetes in the previous 12 months, and a control group of 82 normal pregnancies. Circulating NGAL and insulin resistance by homeostasis model assessment ratio (HOMA-IR) were determined in the first trimester.
Results: Median serum NGAL concentrations were higher in the gestational diabetes group [51.3 ng/ml (39.8–66.1 ng/ml)] compared with the control group [17.8 ng/ml (15.5–20.9 ng/ml)] (P < 0.001) and positively correlated with HOMA-IR (P < 0.001).
Conclusions: In the first trimester, circulating NGAL was significantly increased in women who subsequently developed gestational diabetes compared with the control group.
  F. Corrado , R. D`Anna , G. Di Vieste , D. Giordano , B. Pintaudi , A. Santamaria and A. Di Benedetto
  Aim  To test the hypothesis that myoinositol supplementation will improve insulin sensitivity as measured by markers of insulin resistance such as homeostasis model assessment of insulin resistance and adiponectin in women with gestational diabetes.

Methods  The trial was carried out in diet-treated patients with gestational diabetes diagnosed in our department between April 2008 and September 2009. Subjects were randomly assigned to receive either myoinositol supplementation (4 g daily) plus folic acid (400 μg daily)-the study group-or folic acid only (400 μg daily)-the control group. Both groups received the same diet prescription. Homeostasis model assessment of insulin resistance and adiponectin were assayed while fasting at the time of the diagnostic oral glucose tolerance test and after 8 weeks of treatment.

Results  There were 69 evaluable patients, 24 in the study group and 45 in the control group. Fasting glucose and insulin, and consequently homeostasis model assessment of insulin resistance, decreased in both groups (50% in the study group vs. 29% in the control group), but the decline in the study group was significantly greater than that in the control group (P = 0.0001). Adiponectin increased in the myoinositol group while it decreased in the control group (P = 0.009).

Conclusion  Myoinositol improves insulin resistance in patients with gestational diabetes.

  G Crotti and D. Giordano

The paper analyses some critical situations in the assessment of the compliance with the human exposure limits to the low-frequency magnetic fields. The study is focused on non-sinusoidal and transient waveforms in the frequency range from 8 Hz to 65 kHz. It is carried out by combining measurements and numerical evaluations, starting from actual magnetic flux density behaviours. The results show that inconsistent indications of compliance with the exposure limits may arise not only because of the evaluation method adopted, but also as a result of the used time or frequency windows in relation to the investigated magnetic field waveform.

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