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Articles by D. Dahiru
Total Records ( 3 ) for D. Dahiru
  D. Dahiru and O. Obidoa
  Effects of aqueous extract of Ziziphus mauritiana (Zm) leaf on serum and liver cholesterol and triacylglycerol were studied in chronic alcohol administered rats. Pretreatment co-administration and post treatment protocols were employed. Rats fed alcohol only for 6 weeks had significantly (p<0.05) elevated levels of both serum and liver cholesterol and triglyceride. Pretreatment of rats with 400 mg/kg bw of aqueous extract of Zm leaf prior to alcohol administration significantly (p<0.05) inhibited both levels of serum and liver cholesterol and triglyceride. Co-administration of alcohol with 400 mg/kg bw aqueous extract of Zm leaf significantly (p<0.05) inhibited serum triglyceride level only. Post treatment of alcohol fed rats with 400 mg/kg aqueous extract of Zm for 2 weeks significantly (p<0.05) reduced the levels of both serum and liver cholesterol and triglyceride. Aqueous extract of Zm leaf can be used for the prevention and treatment of fatty liver, atherosclerosis and other diseases associated with high levels of cholesterol and triglyceride. Pretreatment was found to confer more protection than co-treatment, hence pretreatment should be preferred.
  H.A. Umaru , S.A. Iya , W. Obidah and D. Dahiru
  Taurocholate binding capacity (TBC) and water holding capacity (WHC) of twelve wild leafy vegetables commonly consumed in northern Nigeria were studied. Taurocholate binding capacity varied between 17.36±2.58 to 31.02±1.21mg/g. Results obtained showed that Celtis africana had the highest taurocholate binding value of 31.02±1.21 mg/g followed by Hibiscus cannabimis (30.02±1.23) and Balanite aegyptiaca (30.12±3.23mg/g). The lowest taurocholate binding capacity value was observed in Apuim gravealens (21.73±0.25mg/g). While the highest water holding capacity value was observed in Celtis africana (2.24±0.28mg/g), closely followed by Balanite aegyptiaca (2.08±0.11mg/g) and Moringa oleifera (1.88±0.13mg/g). Corchorus oloitoms, Solanium nigrum and Mormodica basalmina had the lowest water holding capacity value (1.02±0.04, 1.21±0.01 and 1.27±0.05mg/g respectively). Thus indicating that these wild vegetables contain high fiber and have the potential to reduce cholesterol considerably from the body and other related diseases.
  D. Dahiru , D.N. Mamman and H.Y. Wakawa
  The aqueous extract of Ziziphus mauritiana fruit (Zm) was evaluated for its protective activity against CCl4-induced liver damage. 250, 500 mg/kg bw of Zm fruit extract or 100 mg/kg silymarin (standard) were administered to different groups of rats prior to CCl4 administration. Both 250 and 500 mg/kg bw of Zm fruit extract significantly (p<0.05) reduced (dose dependently) the levels of enzymes and non-enzymes markers of tissue damage when compared to rats given CCl4 only. These findings were supported by liver histology and suggest that Zm fruit possessed reach hepatoprotective principles that inhibited the toxicity of CCl4 against the liver.
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