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Articles by D. Chen
Total Records ( 3 ) for D. Chen
  C. Wang , L. Lv , X. Wen , D. Chen , S. Cen , H. Huang , X. Li and X. Ran
  Aims The aim of the study was to explore the prevalence and clinical characteristics of hand ulcer in hospitalized patients with diabetes.
Methods We analysed 17 subjects with hand ulcer among diabetic inpatients, who were admitted to the Diabetic Foot Care Center, Department of Endocrinology and Metabolism at the West China Hospital of Sichuan University from April 2003 to December 2008.
Results The prevalence of diabetic hand ulcer among hospitalized patients (0.37%) was significantly lower than that of diabetic foot ulcers (9.7%, = 0.000). The mean age was 62.1 ± 9.4 years. The average known durations of diabetes and glycated haemoglobin (HbA1c) were 5.3 ± 4.9 years and 10.9 ± 2.4%, respectively. All patients lived in the subtropical zone. Fifteen patients (88.2%) were diagnosed with diabetic peripheral neuropathy. Ten patients had hand infection. After therapy, the ulcers healed in 13 patients (76.5%) and none of them experienced amputation. The average hospital stay for patients with local infection was characteristically longer than that for patients without infection (= 0.012). The prognosis of the hand ulcer was poorer in the patients who had diabetes for > 3 years compared with those who had diabetes for < 3 years (= 0.009).
Conclusions Diabetic hand ulcer is a relatively rare complication of diabetes in South-West China. Long duration of diabetes, poorly controlled blood glucose, minor trauma and delayed treatment are the risk factors. Diabetic peripheral neuropathy may play an important role in the pathogenesis of hand ulcer. Early control of blood glucose with insulin and early anti-microbial therapy with appropriate antibiotics are crucial. Debridement and drainage are necessary for hand abscesses.
  G.L. Jiang , G.L. Zhang , S.X. Sun , J. Li , H.J. Xie , D. Chen and M.Y. Tu
  Loquats (Eriobotrya japonica Lindl.) have formed different ecological types in various zones during the long course of their cultivation and acclimatization. The data of biological responses and ecological suitability was very important for loquat plantation in different eco-zones. In this study, we evaluated the growth and development characters, flowering and fruiting habits and fruit quality of loquat in three diverse ecotypes of Sichuan by field survey. The results showed that in mid-subtropical damp and heat ecotype, the loquat trees grew vigorously and young shoots sprouted four times annually. The flower buds were mainly originated from the Summer shoots and the flowering stage most centered from September to December. In addition, a rapid growth stage of fruits was observed from March to April and fruit quality was fine in May. In Southern subtropical dry and hot eco-zone, young shoots might be developed four or five times annually. Flowering and fruiting could occur several times a year as the development differences of Spring and Summer shoots with flower buds differentiation without trees treatments. In the valley of Southern temperate warm and dry ecotype, the phenophase of loquat were late about 20 to 30 days. The loquat fruits were mainly originated from Summer flowerings and mature at June with more than 15% soluble solids, super quality and nice appearance. These results obtained from comprehensive investigation would provide valuable information for techniques of cultivation in distinctive ecotypes and facilitated the economic plantation for loquats in the diverse eco-zones of the world.
  M. Li , G. Ji , F. Feng , W. Song , R. Ling , D. Chen , X. Liu , J. Li , H. Shi , W. Wang and H. Zhang

Objective: We summarized our experience of living-related small bowel transplantation and postoperative management of 3 patients with short gut syndrome.

Methods: Patient #1, an 18-year-old boy, received a 150-cm segment of distal ileum with a vascular pedicle of distal superior mesenteric artery and vein, which was donated by his father. Patient #2, a 15-year-old boy, received a 160-cm graft of distal ileum from his mother. Patient #3, a 17-year-old boy, received a 170-cm graft of distal ileum from his father. The graft artery and vein were anastomosed to the recipient infrarenal aorta and vena cava, respectively, in end-to-side fashion using 7/0 Prolene suture. Intestinal continuity was restored by anastomosis of proximal end of the graft to the recipients' own proximal jejunum, the distal end was left open as a stoma. The recipient distal gut was anastomosed to the distal end of the graft. All 3 recipients were given FK506 (tacrolimus) regularly combined with periodic mycophenolate mofetil. In cases of acute rejection, large doses of steroids were administered to the recipients.

Results: The recipients and donors had fairly unremarkable postoperative courses. So far, patient #1 has survived for 7 years and 6 months with a well-functioning graft and without requirement for total parenteral nutrition (TPN) support. His body weight increased 20 kg and of his life quality has dramatically improved. Patient #2, however, died of acute rejection with fatal sepsis at 5 months after transplantation. Patient #3 has survived for 3 years and 8 months enjoying a normal life. Postoperative recovery of all 3 donors was unremarkable. They were discharged 12 days after surgery without complications.

Conclusion: Outcomes of the implantation using the distal ileum as a graft in living-related small bowel transplantation have been satisfactory for both recipients and donors. It is feasible to anastomose the graft artery and vein to the recipient infrarenal aorta and vena cava. The intestinal continuity can be restored by a 1-stage strategy with minimal risk to the recipient. Appropriate application and adjustment of immune suppressors are crucial for the recipients to experience high-quality lives.
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