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by
D. Senthil Rajan |
Total Records (
2 ) for
D. Senthil Rajan |
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R. Shanmuga Sundaram
,
L. Gowtham
,
R. Rajesh
,
D. Senthil Rajan
,
R. Srinivasan
and
G. Gaurav
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The aim of this study was to investigate the potent neuroprotective property of ethanol extract of Ocimum sanctum leaf (EEOS, Holy basil, Family: Labiataea) against excitotoxicity induced neurodegeneration by using Monosodium-L-glutamate (MSG) in Sprague-Dawley rats. The animals received EEOS (50, 100 and 200 mg kg-1) and memantine (MMT, 20 mg kg-1) daily for 7 days. On all the 7 days, MSG (2 g kg-1, i.p.) was administered one hour before drug treatment. The animals were evaluated for the neurobehavioral performance studies, body weight, food intake, diuretic activity, natriuretic and chloruretic effect immediately after MSG administration from day 1 to day 7. On the day 7, the rats were sacrificed and the brain was removed for histopathological examination. Significant differences in behavioural performance between the control and MSG-treated rats were also found in all paradigms studied. Treatment with EEOS reversed the water-excretory-diuretic effect of MSG and caused a significant dose dependent enhancement in the volume of urine output. An interesting observation made during the study was an increased excretion of Na+ and Cl¯ ions and reduced excretion of K+, in the urine samples of EEOS-treated rats. Therefore, it may be concluded that the decrease in body weight and hypophagia, along with enhanced water intake and diuresis observed in MSG-treated rats were found to be attenuated by treatment with EEOS. Histopathological evaluation showed that treatment with EEOS and MMT significantly protected the neurodegeneration of the CA1 neuronal cells. |
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D. Senthil Rajan
,
M. Rajkumar
,
R. Srinivasan
,
R.P. Harikumar
,
S. Suresh
and
Senthil Kumar KL
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Seaweeds have been used by mankind as medicine and food for
more than 13,000 years. Marine algae are considered to produce a valuable phytoconstituents
characterized by a broad spectrum of antitumor activities. The aim of the present
study was to explore the effect of different solvent extracts of Sargassum
wightii, Greville against Dalton’s
Ascitic Lymphoma (DAL) in Swiss male albino mice. DAL cells were injected intraperitoneally
1x106 cell to the mice. Two days after cells injection the animals
were treated with different solvent extracts of Sargassum wightii at
dose of 200 mg kg-1 for 14 days. 5-fluorouracil (20 mg kg-1)
was used as reference drug. On day 11, cancer cell number, packed cell volume,
decrease in tumour weight of the mice, increase in life span and hematological
parameters were evaluated and compared with the same parameters in control.
A significant increase in the life span and a decrease in the cancer cell number
and tumour weight were noted in the tumour-induced mice after treatment with
the extract. The haematological parameters were also normalized by the ethanolic
and chloroform extracts in tumour-induced mice. These observations are suggestive
of the protective effect of ethanolic extract of Sargassum wightii is
comparatively better than other two tested extracts against Dalton’s
Ascitic Lymphoma (DAL). |
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