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Articles by Clarence S. Yah
Total Records ( 3 ) for Clarence S. Yah
  Jacob M. Ngoy , Sunny E. Iyuke , Clarence S. Yah and Wilhelm E. Neuse
  Problem statement: Folic Acid (FA) is an essential, bioavailable water soluble B-complex vitamin that helps in the replication of normal cells. It is obtained from natural sources and it deficiency can leads to oncogenic cells development. Within this frame work in mind, we designed and synthesized a new bioconjugate carrier that can enhance the effectiveness of FA. Approach: The polymeric carrier: Polysucscinimide (PSI) was synthesized via the polycondensation of aspartic acid by attaching 3-(N,N-Dimethylamino) Propylamine (DMP) and 1,3-P-propylenediamine (PDA) for solubility behavior and reactivity for FA site anchoring. Also the use of an ester 2-(1H-benzotrial-1-yl)-1,1,3,3-tetramethylurium Hexafluorophosphate (HBTU) as coupling agent to FA. The bioreversible binding of the water-soluble and biocompatible macromolecular were attested through kinetic studies. The kinetic reactions were investigated through the nuclear resonance (H1NMR) spectra analysis. Results and Conclusion: The H1NMR optimization reaction times were found within the range of 120-130 min (80-85%) as optimum coupling. The yield of the FA occurred within the same time range but with maximum incorporation between 90-100%. The growth of FA incorporation in terms of reaction time resulted to an increase inherent viscosity relative to the decrease of water solubility of the conjugate obtained.
  Jacob M. Ngoy , Sunny E. Iyuke , Wilhelm E. Neuse and Clarence S. Yah
  In the current concept, covalently functionalized multi-walled carbon nanotube (MWCNT) as a bioconjugate to folic acid (FA); an essential, bioavailable water soluble B-complex vitamin which is usually expressed on the surfaces of most tumoral cells was used. This was rendered possible through the design of a bioreversible binding water-soluble and biocompatible functionalized multi-walled carbon nanotubes (f-MWCNTs). The MWCNT was synthesized through the Chemical Vapor Deposition (CVD). The MWCNTs were covalently functionalized with sulphuric and nitric acids (3:1) at Room Temperature (RT), 50 and 100°C to generate the phenol and carboxyl groups. Furthermore, aspartic acid at 230°C was used to generate the carboxyl f-MWCNTs groups. The CNTs and f-MWCNTs were both characterized with the aid of a Transmission Electron Microscopy (TEM). The results showed a decreased in mol ratio (COOH/OH) of the f-CNTs from 80 to 20 nm as the temperature increases from RT to 100°C. The f-CNTs carboxyl were attached to 3-(N, N-dimethylamino) propylamine (DMP) and FA through 2-(1H-benzotrial-1-yl)-1, 1,3,3-tetramethylurium hexafluorophosphate (HBTU) to generate f-CNTs-FA conjugates. The results of the high resolution nuclear magnetic resonance (H1NMR) and infrared (IR) spectra showed CONH peak shifts bond bioreversible conjugation of FA at 94 and 101.3% and sizes 50 and 170 nm, respectively. The f-MWNT-FA moieties thereby have a greater versatility and can be used for the treatment and restoration of neoplasma cells.
  Clarence S. Yah , Geoffrey S. Simate , Kapil Moothi , Kwena S. Maphutha and Sunny E. Iyuke
  In this study, Carbon Nanotubes (CNTs) were produced through the Chemical Vapour Deposition (CVD) reactor with ferrocene acting as both carbon source and catalyst with argon as the carrier gas. The reaction was carried out at temperatures ranging from 800 to 950°C. Four grams of the ferrocene was placed in a vapouriser at the bottom of the reactor. The system was purged with nitrogen for 20 min to make sure there were no gas leakages as well as free from other gases. The furnace was turned on at the desired temperatures (800-950°C) to produce the CNTs. The CNTs were analysed using the Transmission Electron Microscopy (TEM) and Raman Spectroscopy. The results showed the alignment of multi walled CNTs that ranged between 100 and 1000 nm in length. Furthermore, the CNTs were produced at all the temperatures. However, the optimum temperature for the production of the CNTs was found between 850 and 900°C. The amount of CNTs produced at 800 to 950°C varied from 2.0±0.03 to 2.3±0.34 g at 95% confidence interval with no significant different at p>0.05 using the Instat Program version 5.0.1.
 
 
 
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