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Articles by Ciddi Veeresham
Total Records ( 2 ) for Ciddi Veeresham
  Rajani Garapelli , Ajmeera Rama Rao and Ciddi Veeresham
  Background: Aldose Reductase (AR) enzyme and advanced glycation end products (AGEs) play an important role in diabetic complications. The AR and AGEs inhibitors are beneficial in prevention of diabetic complications. Objective: Aim of present study was to evaluate the in vitro and in vivo AR and AGEs inhibitory activity of an antidiabetic plant Butea monosperma. Methods: The methanolic extract, standardized extract of flower and the major constituent butein were studied for their inhibitory activity against Rat Lens AR (RLAR), rat kidney AR and generation of AGEs. In addition, in vivo inhibition of lens galactitol accumulation in galactose-fed rat model was studied. Results: The plant extracts and butein were shown to possess AR inhibitory activity in both in vitro and in vivo assays with equal potency to that of standard quercetin. In case of inhibited AGEs formation, the plant extracts showed insignificant activity where as butein was found to be potent. Conclusion: The results obtained in this study provide a new dimension to the hitherto unknown activity of the plant as possible protective agent against long-term diabetic complications.
  Cheguri Sowjanya , Ajmera Rama Rao and Ciddi Veeresham
  Background and Objective: People often take different herbs in combination with prescribed modern medication therapy in diabetes and such herbal preparations often contains quercetin that can inhibit cytochrome P450 (CYP)3A4. This enzyme is responsible for metabolizing saxagliptin, which is a potent and specific DPP-4 inhibitor used as anti-diabetic agent. The aim of the present study was that the quercetin may influence the both pharmacokinetic (PK) and pharmacodynamic (PD) interaction of saxagliptin, which could be particularly crucial, as any increment in its plasma levels may raise safety concerns. Materials and Methods: The effect of quercetin on the pharmacokinetics and pharmacodynamics of saxagliptin in normal as well as in streptozotocin (STZ) induced diabetic rats were studied. The data were statistically evaluated using one-way analysis of variance (ANOVA) followed by post hoc Dunnett’s t multiple comparison test using GraphPad Prism 5. Results: In normal and diabetic rats, the combination of saxagliptin with quercetin, significantly increased all the pharmacokinetic parameters, such as Cmax, AUC0-n, AUCtotal, t1/2 and mean residence time and decreased the clearance, Vd, markedly as compared with the control group whereas, PD activity was also altered. Conclusion: The results suggesting that quercetin led to the PK/PD changes because of saxagliptin increased bioavailability and the inhibition of CYP3A4 enzyme. In conclusion, add on preparations containing quercetin may increase the bioavailability of saxagliptin and hence should be cautiously used.
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