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Articles by Chinaka O. Nwaehujor
Total Records ( 2 ) for Chinaka O. Nwaehujor
  Chinaka O. Nwaehujor , Julius O. Ode and Motunrayo G. Akande
  Some plants have been of interest to researchers in West Africa because of their use in the treatment of various disease conditions in Nigerian traditional medicine. The antioxidant activities of 24 herbal plants found in Southern Nigeria were investigated for in vitro anti-oxidant activities using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and Ferric reducing/antioxidant power (FRAP) spectrophotometric assays. Methanol extracts from Uvaria chamae root bark, Bridelia micrantha leaves, Duranta repens leaves, Harungana madagascariensis root bark and Cassytha filiformis stem gave high percentage antioxidant activities with DPPH assay model and significant (p<0.05) concentration-dependent increase in antioxidant power compared to ascorbic acid in the FRAP assay. The extracts of U. chamae root bark and B. micrantha leaves exhibited more appreciable antioxidant capacities compared to ascorbic acid at the maximal test concentration of 400 μg mL-1 in the DPPH assay. The results demonstrated that most extracts had high antioxidant effects and validate their folkloric use as remedies for different ailments. Even in the crude forms, the effects of the extracts were comparable and in some cases, higher than that of ascorbic acid, a compound with proven antioxidant activity. The findings suggest that the six plants named above with high antioxidant activities could be potential sources of novel antioxidants.
  Rita I. Udegbunam , Uzoma I. Asuzu , Raphael O.C. Kene , Sunday O. Udegbunam and Chinaka O. Nwaehujor
  The local anesthetic and tissue effects of the leaf extract and fractions of S. tragacantha were evaluated in this study. The extract 10 and 0.03 mg mL-1 produced 100 and 86% anesthesia, respectively while lignocaine 0.1 and 0.03 mg mL-1 produced 94.4 and 69.4% anesthesia respectively. The fractions showed concentration dependent local anaesthetic effect with fraction 5 being the most active fraction. Fractions 5 and 7 were more potent than lignocaine. Histological examination of skin sections of mice taken on days 1 and 5 post injection of S. tragacantha extract did not reveal any sign of tissue reaction. All fractions contained alkaloids and flavonoids. Three fractions (F5, F6 and F7) contained saponins. This study showed that the extract and fractions of S. tragacantha exhibited local anesthetic activity. The alkaloids and saponins contained in the leaves of S. tragacantha may be responsible for this activity.
 
 
 
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