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Articles by Chenglong Sun
Total Records ( 2 ) for Chenglong Sun
  Xiaohu Wang , Yuzhu Jin , Chenglong Sun , Shoufeng Zhang , Ziguo Yuan , Zhuang Ding and Rongliang Hu
  Rabies virus is a kind of virus having strict neurotropic property. Intracerebral inoculation method was commonly used to RV-related research. SRV9 is an attenuated RV vaccine strain. In the present study, we inoculated intracerebrally on suckling mouse with SRV9 strain. The results showed that SRV9 could cause a mortality rate of 100% on suckling mice below 13 day old. The mortality rates of 14-17 day old mice were 68, 33, 33 and 17%, respectively without incidence above 18 day old. Meanwhile, the results showed that the growth of survival suckling mice was inhibited remarkably after intracerebral inoculation SRV9. The 16 day old survival suckling mice were chosen to perform body weight test and the result showed that the weight growth was very slow with 14% less than normal growth rate. However, 2 weeks latter the weight of the mice began to recover gradually but slowly. It was suggested that the intracerebral RV reproduction could take a significant effect on the growth and development of the mice and with RV being eliminated by antibody, the weight of the mice which were inoculated with SRV9 could gradually recover.
  Naijun Han , Yewei Li , Chenglong Sun , Qingguo Meng , Feifei Song , Yang Yang , Shoufeng Zhang and Rongliang Hu
  The rabies virus glycoprotein is an efficient vaccine antigen particularly for the oral vaccine of wildlife. Pseudorabies virus contains many non-essential genes and was usually used to construct recombinant vaccines as a viral vector to deliver foreign genes into the target animals. In this study, a recombinant pseudorabies virus rPRV/SRV9G/EGFP, expressing EGFP and rabies virus (SRV9 strain) glycoprotein was constructed by homologous recombination in the UL21 gene. The immunogenicity was evaluated as a vaccine in mice. In this trial, thirty mice were administered with the recombinant vaccine orally. This recombinant virus was demonstrated to be safe for mice by oral administration and could induce neutralizing antibody level above 0.5 IU mL-1 at 3 weeks after the vaccination. The results suggest that rPRV/SRV9G/EGFP was an effective oral vaccine candidate against rabies and UL21 gene could be a target insertion area for foreign genes.
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