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Articles by Chehregani Abdolkarim
Total Records ( 1 ) for Chehregani Abdolkarim
  Ranjbar Akram , Ghasemi Hassan , Hossini Zijoud Seyed-Mostafa , Mohsenzadeh Fariba , Chehregani Abdolkarim and Soleymanian Tayebeh
  Background and Objectives: Paraquat (PQ), one of the most widely used herbicides, is highly toxic to humans and animals. There is much information regarding its toxic effects on the lungs, but less is known about its toxicity in other organs. PQ is thought to play pivotal roles in the pathophysiology of acute renal failure and the progression of chronic kidney disease. The aim of this study was the effect of hydroalcoholic extract Matricaria chamomilla L. (M. chamomilla) against PQ-induced kidney injury in association with its antioxidant activity. Methodology: The male rats were treated with gavages’ daily with PQ (5 mg/kg/day) and M. chamomilla (50 mg/kg/day) were administered alone or in combination for 7 days. After treatments, blood urea nitrogen and creatinine levels, Total Antioxidant Capacity (TAC), total thiol molecules (TTG) levels and catalase CAT activity in kidney tissue were measured. Results: Rats administered PQ showed increased blood urea nitrogen and creatinine levels and CAT activity, TAC and TTG was decreased compared with control rats. Co-administration of PQ with M. chamomilla extract increased TAC and TTG in kidney tissue as compared with PQ group. Conclusion: These results showed that PQ-induced nephrotoxicity may be caused by oxidative damage in rat kidneys and that M. chamomilla could protect kidneys from PQ-induced toxicity.
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