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Articles by Charles S. Vairappan
Total Records ( 2 ) for Charles S. Vairappan
  Nagi A. Al-Haj , Nurmas I. Mashan , Mariana N. Shamsudin , Habsah Mohamad , Charles S. Vairappan and Zamberi Sekawi
  The in vitro antibacterial activities of seaweed belong to Euchema denticulatum extract showed inhibitory activity only on gram positive organisms tested including Staphylococcus aureus and Streptococcus pyogenes, which were expressed in terms of minimum inhibitory concentration and minimum bactericidal concentration test. Thus, gram negative pathogens tested including Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa showed resistant phenotypic pattern to both extracts. Results of the present study confirmed the potential use of seaweed extract as a source of antibacterial compounds.
  Nagi A. AL-Haj , Nurmas I. Mashan , Mariana N. Shamsudin , Habsah Mohamad , Charles S. Vairappan and Zamberi Sekawi
  Gram-positive bacteria are more sensitive to antibiotics than gram-negative bacilli because of the lack of outer membrane which prevent easy access of the drug into the bacterial cells. However, there are many gram-positive organisms with natural, intrinsic resistance to antimicrobials. In addition, these bacteria are able to acquire resistance to frequently used drugs rapidly through selective pressure of the environment and also via the genetic evolution of bacteria. The resistance of those bacteria to antibacterial agents is mediated by antibiotic resistant genes. Therefore, the current study was designed to explore the effect of seaweed extracts on several antibiotic resistant genes in Staphylococcus aureus mec genes mecA, mecR1 and mecI that regulate the expression of methicillin resistance was investigated by PCR.
 
 
 
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