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Articles by Changgang Huang
Total Records ( 1 ) for Changgang Huang
  Yanqing Wang , Willy R.G. Baeyens , Changgang Huang , Guangtao Fei , Li He and Jin Ouyang
  This paper describes the enhanced separation of lomefloxacin, sparfloxacin, fleroxacin, norfloxacin, ofloxacin, gatifloxacin and pazufloxacin by capillary zone electrophoresis (CZE) using silica nanoparticles (SiNPs) as running buffer additive. The impact of SiNPs concentration on the resolution and selectivity of separation was investigated and a given value of SiNPs was finally chosen under the optimum conditions. The addition of the SiNPs to the running buffer enabled electroosmotic flow (EOF) decrease and permitted full interaction between SiNPs and analytes. The influence of separation voltage, pH and buffer concentration on the separation in the presence of SiNPs was examined. Interactions between drugs and nanoparticles during the separation are discussed; the determination of interaction constants is also achieved. A good resolution of seven quinolones was obtained within 15min in a 50cm effective length fused-silica capillary at a separation voltage of +10kV in a 12mM disodium tetraborate-phosphate buffer (pH 9.08) containing 5.2μgmL−1 SiNPs.
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