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Articles by Chang-Won Pyun
Total Records ( 2 ) for Chang-Won Pyun
  Go-Eun Hong , P.K. Mandal , Chang-Won Pyun , K. Choi , Soo-Ki Kim , Kyu-Ho Han , M. Fukushima , Ho-Chul Shin and Chi-Ho Lee
  This study was done to investigate the effects of fermented soy pulp on the osteoporosis in ovariectomized rats. Sprague-Dawley female rats were randomly assigned to four groups as Sham Control (SC), Ovariectomized Control (OC), Ovariectomized and Soy Pulp (OSP) fed and Ovariectomized and Fermented Soy Pulp (OFSP) fed. All rats were fed on purified diets, supplemented with non-fermented and fermented soy pulp on basic diet for 7 weeks. It was observed that isoflavone aglycone was very high in soy pulp fermented for 12 h in comparison to non-fermented soy pulp. Body weight of the rats increased significantly (p<0.05) in comparison to other groups. Atrophy of uterus in OFSP group was significantly (p<0.05) prevented in comparison to OC group. The concentration of estradiol in OFSP group was higher than those of OC and OSP groups. The bone density in OFSP group was significantly (p<0.05) higher than those of OC and OSP groups. The histopathology indicated that OFSP group has better retarded the progress of osteoporosis than other groups. The results showed that isoflavone from the fermented soy pulp has prevented the osteoporosis in ovariectomized rats must be due to its estradiol like function. It is expected that the fermented soy pulp might serve as a functional food in osteoporosis of postmenopausal women.
  Go-Eun Hong , Chang-Won Pyun , Sang-Min Jeong , Kyu-Ho Han and Chi-Ho Lee
  This study was performed to determine the effects of fermented Pueraria radix on lipid and bone metabolism in ovariectomized (OVX) rats. Sprague-Dawley rats were divided into 4 groups: A sham operated control group, an OVX control group, an OVX group, treated Pueraria radix and OVX group treated fermented Pueraria radix. Rats were fed experimental diets with Ca and P free for 8 weeks after ovariectomy. The femur weight was significantly increased in the treatment groups, compared with that of the control group. Abdominal fat mass and serum alanine aminotransferase and aspartate aminotransferase activities and serum triglyceride, total cholesterol, LDL-cholesterol and osteocalcin levels in the treatment groups were significantly decreased compared with the control group. Serum estradiol level in the treatment groups was significantly increased compared with the control group. Bone mineral density of the femur in the fermented Pueraria radix treatment groups was significantly increased than the control group. Further, the result of histopathologic observation was shown in that the treatment of Pueraria radix and fermented Pueraria radix prevented trabecular loss. These results suggest that a P. radix powdered supplement as a source of isoflavones might ameliorate serum cholesterol and estradiol levels and protect against bone loss. Furthermore, fermented P. radix might be more effective than non-fermented P. radix and can be useful as a functional food.
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