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Articles by Chang-Gu Hyun
Total Records ( 5 ) for Chang-Gu Hyun
  Young Min Ham , Kil-Nam Kim , Wook Jae Lee , Nam Ho Lee and Chang-Gu Hyun
  By bioactivity-directed fractionation, three antioxidant constituents have been characterized from Sargassum micracanthum collected in Jeju Island, Korea. The potent antioxidant elucidated sargaquinoic acid, sargachromenol and fucosterol by NMR and mass spectroscopic data. The free radical scavenging activities of the sargaquinoic acid, sargachromenol and fucosterol were investigated in relation to 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radicals using an Electron Spin Resonance (ESR) system. The sargaquinoic acid and sargachromenol were found to scavenge DPPH (IC50, 49.3 and 100.2 μM). Therefore, these results resent sargaquinoic acid and sargachromenol with a potent antioxidative activity that could be useful in cosmetics, foods and pharmaceuticals.
  Kil-Nam Kim , Young-Min Ham , Min-Seok Yang , Dong Sam Kim , Wook Jae Lee , Nam Ho Lee and Chang-Gu Hyun
  Many seaweed species are used as traditional medicine in different parts of the world. However, little data on the anti-cancer effect of seaweed has been published. In this study, we investigated the ability of ethyl acetate extracts of Scytosiphon gracilis Kogame (SGE) to induce apoptosis in cultured human promyelocytic leukemia HL-60 cells. Treatment of HL-60 cells with various concentrations of SGE extracts (12.5-100 μg mL-1) exhibiting IC50 values of 15.68 μg mL-1 resulted in sequences of events marked by apoptosis, such as loss of cell viability, morphology change and internucleosomal DNA fragmentation. The SGE-induced apoptotic cell death was associated with caspase-3 and -9 activation and poly ADP-ribose polymerase degradation in HL-60 cells. This increase in SGE-induced apoptosis was also associated with a reduction in the levels of Bcl-xL, a potent cell-death inhibitor and an increase in levels of the Bax protein, which heterodimerizes with and thereby, inhibits Bcl-2. Present findings suggested that S. gracilis exerts antiproliferative action and growth inhibition on human promyelocytic leukemia HL-60 cells through a mitochondria-dependent apoptotic pathway. Therefore, S. gracilis may have anticancer properties valuable for application in food and drug products.
  Jung Eun Kim , Sang Suk Kim , Chang-Gu Hyun and Nam Ho Lee
  Chemical investigation to identify the antioxidative constituents from the stems of a tree Cleyera japonica Thunb. resulted in the isolation of seven compounds: catechin (1), catechin 3-O-α-L-rhamnopyranoside (2), epicatechin (3), taxifolin (4), taxifolin 3-O-α-L-arabinopyranoside (5), taxifolin 3-O-α-L-rhamnopyranoside (6) and proanthocyanidin A-1 (7). These isolates were studied for their scavenging activities against DPPH radical, hydroxyl radical and superoxide anion radicals using spectrophotometry and/or electron spin resonance. All isolates 1-7 exhibited more potent DPPH radical inhibition activities than the positive control, ascorbic acid. In the hydroxyl radical scavenging test, compound 7 (SC50 301.6 μM) showed potent activity higher than ascorbic acid (SC50 859.7 μM). All of the compounds 1-7 exhibited comparable activities to ascorbic acid for superoxide anion radical scavenging. These results demonstrated that C. japonica stem extracts could be potentially used as antioxidative agents in food or cosmetic applications.
  Ha Na Ko , Tae-Heon Oh , Jong Seok Baik , Chang-Gu Hyun , Sang Suk Kim and Nam Ho Lee
  Development of natural products possessing anti-inflammatory activities has been the focus of research in our laboratory. In this study, the extract from Carpinus turczaninowii branches was studied and their anti-inflammatory constituents were identified. The aqueous ethanol extract was fractionated successively to afford n-hexane, ethyl acetate, n-butanol and aqueous layers. Upon anti-inflammatory tests for Nitric Oxide (NO) production, using RAW 264.7 cells, the ethyl acetate fraction exhibited potent inhibitory activities without causing cell toxicities. The ethyl acetate fraction was subjected to further purification to isolate carpinontriol A and carpinontriol B as active constituents. These diarylheptanoid compounds were isolated for the first time from this plant. The isolates reduced the lipopolysaccharide (LPS)-induced secretion of NO and IL-6 productions in a dose-dependent manner in RAW 264.7 cells which indicates their anti-inflammatory effects. Based on these results, it was suggested that C. turczaninowii extracts containing carpinontriols A and B could be considered potential anti-inflammatory agents for pharmaceuticals or cosmetics.
  Chunsuk Kim , Sun Joo Lee , Chang-Gu Hyun and Nam Ho Lee
  Essential oils, volatile compounds from plants, are attractive natural ingredients possessing wide range of applications in cosmetics, foods, household products and alternative medicines. In this study, the three different oils from Prunus yedoensis (PYE), Saururus chinensis (SCE), Zanthoxylum piperitum (ZPE) were prepared by supercritical carbon dioxide extraction and their chemical components were analyzed. In addition, their anti-inflammatory activities were investigated by measuring the inhibition of pro-inflammatory cytokines. Monoterpenes α-Pinene (22.4%), 2-β-pinene (20.1%) and camphor (13.1%) were found as the major components in PYE. In the case of SCE, sesquiterpenes δ-cadinol (22.5%) and δ-cadinene (19.7%) as well as a diterpene trans-phytol (13.7%) were mainly identified. The major chemical constituents of ZYE were in the order of octanoic acid (13.4%), n-heptanol (9.8%) and 1-octanol (8.1%). As a bioactivity study, the effects of PYE, SCE and ZPE on nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 production in lipopolysaccharide-activated RAW 264.7 macrophages were examined. These essential oils (PYE, SCE, ZPE) were appeared to considerably suppress the production of pro-inflammatory cytokine and mediators in dose-dependent manner. The results indicate that PYE, SCE and ZPE can be useful natural agents to manage inflammatory symptoms and diseases.
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