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Articles by Chanchal Deep Kaur
Total Records ( 7 ) for Chanchal Deep Kaur
  Mukesh K. Singh , Bina Gidwani , Anshita Gupta , Hemant Dhongade , Chanchal Deep Kaur , Pranita P. Kashyap and D.K. Tripathi
  In the genus Orthosiphon (Lamiaceae), Orthosiphon aristatus, Orthosiphon pallidus, Orthosiphon thymiflorus, Orthosiphon stamineus are widely used in traditional medicine to prevent different diseases such as diabetes, kidney stone, edema, rheumatism, hepatitis, hypertensive and jaundice. A different variety of phytoconstituents has been isolated from the Orthosiphon species which include monoterpenes, diterpenes, triterpenes, saponins, organic acid and flavonoids compound. Antidiabetic, anti-inflammatory, antioxidant, hepatoprotective, analgesic and nephroprotective activities have been reported in the plant extract and phytoconstituents. Hence, the purpose of this review is to provide a comprehensive report about the Orthosiphon genus based on its toxicity in order to identify its therapeutic potential and future prospects for betterment of research.
  Tarun Kumar , Anshita Gupta , Bina Gidwani and Chanchal Deep Kaur
  Euphorbia tithymaloidus is a shrub having a range of activities like anti-inflammatory, antioxidant, anti-malarial, anti-tuberculosis, antifungal, antibacterial, antidaibetic and wound healing etc., but the anthelminthic activity of this plant is still under consideration. In this study carried out the phytochemical and anthelminthic activity of Euphorbia tithymaloidus in order to estimate its potential in treating the intestinal worms. The in vitro anthelmintic activity was performed on ethanolic leaf extract using adult earthworms (Pheretima posthuma). The standard drug used was albendazole in the concentration of 15-60 mg mL–1 to note the paralysis time and death time. The result of the study showed that the ethanolic leaf extract shows the presence of certain phytoconstituents like flavonoids, carbohydrates, steroids and alkaloids. The reaction time was noted as paralysis time and death time for all the concentrations and compared with standard albendazole. The extract exhibited remarkable activity at a concentration of 45 mg mL–1 as compared to standard drug albendazole within a shorter time span of less than 10 min.
  Sneha Sahu , Swarnlata Saraf , Chanchal Deep Kaur and Shailendra Saraf
  This study describes the release and retention of a herbal lipophilic drug in sustained and controlled manner in skin layers, given topically, intended for skin cancer. Quercetin -loaded nanoparticles were prepared by nanoprecipitation technique using ethylcellulose as polymer. Ethylcellulose was selected as it is biocompatible, but non-biodegradable and hence can act as a reservoir in skin furrows and ducts. It was observed that the Quercetin: Ethylcellulose: Tween 80 at different ratios affects particle sizes along with yield and entrapment efficiency. It was found that the size of nanoparticles could be varied by changing the speed of agitation and sonication. The nanoparticles were prepared in particle size range 228.77±2.0 nm and the zeta potential of the selected formulation were found to be -16.7 mV, which shows the stability of the preparation. The percent entrapment efficiency was found to be in the range from 51.96 to 53.93% and percent loading capacity in the range 34.19 to 5.12%. The amount of drug release from nanoparticles and of drug retained in skin was compared using ex vivo study which shows that the drug being lipophilic could be retained in the skin for longer duration thus reducing the dose and frequency of drug administration. Further the amount of drug reaching to other organs is also reduced since the systemic absorption of drug was low. Thus, Quercetin loaded nanoparticles were prepared for topical use.
  Swarnlata Saraf , Anshita Gupta , Chanchal Deep Kaur , Manmohan Jangde and Shailendra Saraf
  Photosensitization is a process in which the skin reacts to exposure to ultraviolet radiations. There are various associated dermatological consequences like photoxicity and photoallergic reactions which make the disease more complicated. There are various drugs which together with solar radiations worsen the situation of photosensitivity and hence termed as photosensitizers. The developments on the use of phytoconstituents from the herbal extract is the ardent need for fighting against the deleterious photosensitization reactions. This review attempts to highlight the problems of photosensitivity its pathological manifestation with the approach to treat them naturally with the help of skin rejuvenating herbs.
  Chanchal Deep Kaur and Swarnlata Saraf
  Herbs having polyphenolic constituents are antioxidant in nature and are used for combating the deleterious effects of ultraviolet radiations thus producing photoprotective effects. The herbs selected were turmeric (dried rhizomes) and pomegranate (dried seeds) which could produce photo protective effect. The alcoholic extracts were produced by continuous hot extraction method taking 90% v/v ethyl alcohol and preliminary phytochemical identification tests were performed for the detection of constituents. Total polyphenol content of the extracts was measured using the Folin-Ciocalteu colorimetric method and antioxidant effect by reducing power estimation method in which the antioxidant activity of extract was compared with that of standard (ascorbic acid). Creams were developed taking 0.5, 1 and 2% extracts individually and evaluated for physicochemical parameters and long term skin hydration studies. Present studies showed that the selected herbal extracts have photoprotective properties in which the total phenolic content and antioxidant activity of Punica granatum extract was obtained higher than Curcuma longa extract. The skin hydration studies of P. granatum extract loaded creams show significantly improved hydration as compared to Curcuma longa extract loaded creams.
  Swarnlata Saraf , Avijit Ghosh , Chanchal Deep Kaur and Shailendra Saraf
  Targeting of drugs and bioactives to lymphatic system is very challenging and it depends upon the complex physiology of the lymphatic system. Targeting helps in achieving the aim of direct contact of drug with the specific site, decreasing the dose of the drugs and minimising the adverse effects caused by them. Use of nanosystem has promoted the lymphatic targeting; but still there are challenges of detecting specific sites, maintaining desired action, crossing all the physiological barriers. These hurdles could be overcome by the use of modified nanosystems achieved by the surface engineering. This review provides a summation of physiology of lymphatic system, different physicochemical parameter and their effect on lymphatic system, solute uptake by lymphatic system, different lymphatic targeting areas, strategies for surface engineering, different techniques of surface modification, detail of work done related to the drug delivery systems for lymph targeting like liposomes, nanoparticles, nanocapsules etc. This review will provide a platform for researchers working in this area of treating abnormalities related to lymphatic system with new approach of surface modification of various novel nanosystems.
  Swarnlata Saraf , Dhani Ram Patel , Chanchal Deep Kaur and Shailendra Saraf
  Cytoskeletons are the proteins contained within the cytoplasm and responsible for many cellular and physiopathological events such as maintenance of cell shape, chromosome aggregation, mechanical support to cells, muscle contraction, provide mechanical strength etc. Cytoskeletons are of three major types: Microfilaments, intermediate filaments and microtubules. They are collectively responsible for providing most of the structure and spatial organization in the cell. In this review, we focus on the drugs, bioactive and other active agents which act on the cytoskeletal elements and also emphasize on the method used to visualize or analyze the cytoskeleton structures and elements. Different classes of cytoskeleton acting drugs, agents, their importance, target area and their mode of action are also focused in this review with the contribution of the different instruments for the analysis of cytoskeleton types which are important for the drug targeting.
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