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Articles by Cemile KOCA
Total Records ( 2 ) for Cemile KOCA
  Remzi KARADAG , Cemile KOCA , Yuksel TOTAN , Ramazan YAGCI , Murat AYDIN , Ayse Serap KARADAG , Gulfer AKBAY , Meral EKSIOGLU and Ramazan YIGITOGLU
  Aim:The aim of this study was to elucidate serum levels of IL-6, IL-8, TNF-α, CRP, and HSP 70 in patients with active or inactive Behcet`s disease.
Materials and methods: The study included 50 patients who met the International Study Group criteria for Behcet`s disease. Of these, 26 had active disease and 24 had inactive disease. The control group was comprised of 25 age- and sex-matched healthy participants. Serum levels of IL-6, IL-8, TNF-α , CRP, and HSP 70 were measured.
Results: In patients with active disease, significantly higher mean serum levels of IL-6, IL-8, TNF-α, and CRP were found compared to patients with inactive disease or in controls (overall, P < 0.05). In patients with active disease, the mean serum level of HSP 70 was significantly higher than that of the control group (P = 0.02). In patients with inactive disease it was higher compared to the controls but with a significance level close to 0.05 (P = 0.044). However, HSP 70 levels did not differ significantly between patients with active disease and patients with inactive disease (P = 0.93).
Conclusion: The results of our study suggest that serum IL-6, IL-8, TNF-α, and CRP levels are increased in patients with active Behcet's disease. HSP 70 levels in both active and inactive disease groups were higher than in controls, though it was significant only in the active group. This suggests that HSP 70 has a role in the chronic nature of Behcet`s disease, with HSP 70 expression possibly not falling to normal levels in the inactive phase of the disease.
  Ozlem KIRMEMIS , Mustafa Mansur TATLI , Cuneyt TAYMAN , Cemile KOCA , Ahmet KARADAG , Nurdan URAS , Ugur DILMEN and Hasan KAFALI
  Aim: To test the hypothesis that serum S100B levels could be useful in detecting neurological damage in infants with intrauterine growth retardation (IUGR). Materials and methods: The study group consisted of infants with IUGR and the control group consisted of age-matched healthy infants. S100B protein levels were measured after birth and compared between groups. Results: For this study, 43 infants with IUGR and 25 infants as a control group were recruited. Gender, gestational age, type of delivery, and maternal age of the groups were statistically insignificant, with the exception of the mean birth weights (2120 ± 450 g in the IUGR group and 3096 ± 570 g in the control group (P < 0.001), respectively). S100B protein levels of the IUGR infants (1.13 ± 0.54) were significantly higher than those of the control group (0.45 ± 0.13) (P < 0.001). IUGR infants treated with antenatal steroids showed lower S100B levels than IUGR infants that did not receive antenatal steroid treatments (P < 0.05). The study group infants were divided into 2 groups, for growth retardation (GR) that was asymmetric (n = 15) and symmetric (n = 28). The asymmetric and symmetric GR infants’ S100B levels were 1.14 ± 0.47 pg/mL and 1.21 ± 0.34 pg/mL, respectively, and no significant differences were found between the 2 groups in terms of S100B levels (P = 0.32). Conclusion: The results of this study favor the opinion that there is an existing intrauterine hypoxia causing hypoxic brain tissue damage in IUGR infants, even when followed up with modern obstetrical screening protocols. Measurements of S100B may be useful in the prediction of outcome in these infants.
 
 
 
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