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Articles by C.O. Nwaigwe
Total Records ( 2 ) for C.O. Nwaigwe
  C.O. Nwaigwe , C.A. Nwankpa and C.U. Nwaigwe
  This study was carried out in order to determine the effect of three test rations comprising Brachiaria ruziziensis grass silage and sawdust/poultry litter silage which replaced some conventional feed ingredients (wheat offal, soya bean cake and maize offal) at varying levels in the diets of goats. Twelve young West African dwarf does with mean ages and weights of 6±0.17 months and 4.2±0.44 kg, respectively, randomly divided into three groups of four replicates were used for the study which lasted for forty-five days. The animals were fed three test rations with sawdust/poultry litter silage replacing 50% (Diet 1), 25% (Diet 2) and 0% (Diet 3 or Control. In addition, all groups received Brachiaria ruziziensis grass silage at 5% inclusion level. Parameters measured include Production attributes, Haematology and serum biochemistry. Results showed that the haematological and serum biochemical parameters showed no significant differences (p>0.05) among groups. However, significant differences (p>0.05) existed in the production attributes with respect to mean final gain, mean daily gain, mean daily intake, mean total feed intake and apparent protein digestibility, feed conversion efficiency, but not in their rumen motility. Cost of production was significantly (p<0.05) lowest in diet 1 compared to diets 2 and 3, respectively. It was observed that sawdust/poultry litter silage was most beneficial at 25% inclusion level as animals fed this diet had significantly higher weight gain and better feed conversion efficiency compared to those of 50% and Control groups.
  C.U. Nwaigwe , I.I. Madubunyi , S.C. Udem and C.O. Nwaigwe
  The hepatoprotective activity of Olax viridis Oliv. (Olacaceae Juss.) methanol root extracts were tested in vivo and in vitro. The plant material was defatted with n-hexane and extracted with 70% methanol, respectively. The methanol extract was recovered in 11.73% w/w yield. An oral 100 mg kg-1 administration of the methanol extract significantly reduced pentobarbitone-induced sleep in rats poisoned with acetaminophen (p<0.05). In this model, a protection of 87% against the cytotoxicity of acetaminophen was obtained by pretreatment with the methanol extract as compared to a protection of 91% when the animals were pretreated with silymarin. The n-hexane extract was without a significant hepatoprotective effect in this model. Intraperitoneal injection of the methanol extract into rats showed no significant effect on pentobarbitone-induced hypnosis (p<0.05). The elevation of serum glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP) and urea induced by paracetamol intoxication in rats was also significantly attenuated by the methanolic extract (p<0.05). These findings demonstrated that O. viridis root extract has protective effects on experimental model of liver diseases in rats and validates its use in Nigerian traditional medicine for the prevention of liver diseases. Even in its crude form, the effects were comparable to that of silymarin, a flavanolignan with proven antihepatotoxic activity. This suggests that the extract could be a potential source of a novel antihepatotoxic agent.
 
 
 
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