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Articles by C.G. Nkwonta
Total Records ( 2 ) for C.G. Nkwonta
  C.G. Nkwonta , C.A. Ezeokonkwo and I.C. Obizoba
  The nutritional potential of moist and dry heat treated Tetracarpidium conophorum nut was evaluated using male albino rats (45-55 g). Twenty-four (18) weanling rats were divided into three groups of six rats each on the basis of body weight. These rats were fed for thirty-five (35) days. Caesin (CAS), Boiled T. conophorum (BTC) and Roasted T. conophorum (RTC) were fed these three (3) groups of rats respectively. All chemicals and statistical analysis were based on modern techniques. In vivo bioassay revealed that growth food and nitrogen intakes and Protein Efficiency Ratio (PER) were higher in rats fed the RTC diet than in rats fed the BTC diet. However, rats fed the BTC diet gained more weight than those fed the RTC diet. The rats fed the RTC diet had higher food and nitrogen intakes, faecal digested and retained nitrogen, Biological Value (BV) and Net Protein Utilization (NPU) than rats fed the BTC diet. Rats fed the test diets-RTC and BTC- had more than 95% N intake, digested and retained nitrogen. The results indicate that dry-heat treatment improved Nitrogen availability in T. conophorum than moist-heat.
  C.S. Ezeonu , P.A.C. Egbuna , L.U.S. Ezeanyika , C.G. Nkwonta and N.D. Idoko
  The antihepatotoxic effect of ethanolic extract of ginger (Zingiber officinale) against CCl4 (10 mL kg-1 body weight) were investigated. Total 7 groups of rats were used in the investigation with alternative methods of administration of ginger extract and CCl4 both at 24 h intervals as well as simultaneous administrations. All the administration methods involved injection of the substances intraperitoneally. Serum Glutamate Pyruvate Transaminase (SGPT) and Serum Glutamate Oxaloacetate Transaminase (SGOT) decreased significantly (p<0.05) when ginger ethanolic extract was administered first (1000 mg kg-1 body weight) followed by CCl4 24 h later. Injection of CCl4 followed by ethanolic ginger extract 24 h later gave a reduction in the serum enzyme but not as much as when ginger extract was first administered. The same result above was also obtained for lipid peroxidation production. Protein synthesis was not affected by the various groups although, CCl4 and ethanolic extract of ginger caused increase in serum protein which did not show any significant increase (p>0.05). Inorganic phosphate was increased by both CCl4 and ethanolic extract administration. Fraction D was shown to have more hepatoprotective effect than even the ethanolic extract itself. Administration of ginger extract and CCl4 simultaneously had the least hepatoprotective effect. Thus, preventive intraperitoneal administration of ginger ethanolic extract before liver injury had the highest efficacy against hepatotoxic induction using CCl4.
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