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Articles by C.A. Ezeokonkwo
Total Records ( 2 ) for C.A. Ezeokonkwo
  A.C.C. Egbuonu , C.A. Ezeokonkwo , P.M. Ejikeme , O. Obidoa and L.U.S. Ezeanyika
  The present study is aimed at substantiating whether monosodium glutamate, MSG, could induce toxic effects at an appreciably lower dose and to examine the possible role of arginine, ARG, on such MSG-induced effects. Thus, MSG at a dose of 5 mg kg-1 body weight was administered to adult male Wistar rats by oral intubation. Treatment was daily and lasted for 28 days. The MSG treatment significantly (p<0.05) decreased the serum alkaline phosphatase (ALP) activity (71.97%) but increased the activities of the serum total acid phosphatase (TAP) (6222.80%) and the serum Aspartate Amino Transferase (AST) (66.86%) and the serum aspartate aminotransferase-to-alanine aminotransferase (AST-to-ALT) ratio (56.59%). Arginine (ARG) (20 mg kg-1 b.wt.) co-administered with MSG significantly (p<0.05) decreased the serum Alkaline Phosphatase (ALP) activity (90.47%) representing a decrease of only 18.50% relative to the MSG-treatment alone, but increased the serum Total Acid Phosphatase (TAP) activity (11119.27%), the serum Aspartate Aminotransferase (AST) activity (133.35%) and the serum aspartate aminotransferase-to-alanine aminotransferase (AST-to-ALT) ratio (147.25%). The results showed that MSG at a dose of 5 mg kg-1 b.wt. probably affected the synthesis of the above enzymes and that ARG at 20 mg kg-1 b.wt. potentiated the MSG-induced effects. Thus, ARG at 20 mg kg-1 b.wt. may significantly exacerbate the possible MSG-induced adverse effect on the prostate and major organs with high metabolic activities especially the liver.
  C.G. Nkwonta , C.A. Ezeokonkwo and I.C. Obizoba
  The nutritional potential of moist and dry heat treated Tetracarpidium conophorum nut was evaluated using male albino rats (45-55 g). Twenty-four (18) weanling rats were divided into three groups of six rats each on the basis of body weight. These rats were fed for thirty-five (35) days. Caesin (CAS), Boiled T. conophorum (BTC) and Roasted T. conophorum (RTC) were fed these three (3) groups of rats respectively. All chemicals and statistical analysis were based on modern techniques. In vivo bioassay revealed that growth food and nitrogen intakes and Protein Efficiency Ratio (PER) were higher in rats fed the RTC diet than in rats fed the BTC diet. However, rats fed the BTC diet gained more weight than those fed the RTC diet. The rats fed the RTC diet had higher food and nitrogen intakes, faecal digested and retained nitrogen, Biological Value (BV) and Net Protein Utilization (NPU) than rats fed the BTC diet. Rats fed the test diets-RTC and BTC- had more than 95% N intake, digested and retained nitrogen. The results indicate that dry-heat treatment improved Nitrogen availability in T. conophorum than moist-heat.
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