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Articles by C.A. Danquah
Total Records ( 2 ) for C.A. Danquah
  E. Woode , E. Boakye-Gyasi , C.A. Danquah , C. Ansah and M. Duwiejua
  The anti-arthritic effect of an ethanolic leaf extract of Palisota hirsuta, a plant used locally in Ghana for various painful inflammatory conditions was assessed, using the Freund’s adjuvant induced-arthritis model in rats. Palisota hirsuta Extract (PHE) as well as dexamethasone and methotrexate, used as positive controls, showed significant dose-dependent anti-arthritic properties prophylactically, curatively and also in combination therapy. PHE (30-300 mg k-1) significantly reduced the arthritic edema in the ipsilateral paw with the highest dose used giving a maximum inhibition of 13.02±8.77%. PHE 300 mg k-1 also significantly prevented the spread of the edema from the ipsilateral to the contralateral paw indicating inhibition of systemic spread. Dexamethasone (0.3-3 mg k-1) and methotrexate (0.1-1.0 mg k-1) significantly and in a dose dependent manner also inhibited polyarthritis edema as well as completely preventing the spread of the arthritis from the ipsilateral to the contralateral paws of the treated animals. PHE in combination with methotrexate did not show any significant effect, however, there was a significant inhibition of arthritis in both the acute and the polyarthritis phases when PHE was combined with dexamethasone. Dexamethasone in combination with methotrexate gave the greatest inhibition of both phases with an extreme level of significance as expected. Overall, the present results demonstrate that PHE has anti-arthritic effect which could be similar to that exhibited by methotrexate.
  E. Woode , C.A. Danquah , E. Boakye-Gyasi , C. Ansah and G. Ainooson
  Antinociceptive effect of an ethanolic extract of Capparis erythrocarpos Isert roots (10-300 mg kg-1; p.o.) was evaluated in the mouse formalin test. Morphine (1-10 mg kg-1; i.p.) was used as positive control. The extract dose-dependently reduced pain scores in both phases of formalin-induced nociception with the 100 mg kg-1 dose significantly reducing formalin-induced pain by 47.54±5.65 and 80.01±3.77% in the first and second phases, respectively. Naloxone (an opioid antagonist) did not block the antinociceptive effect of the extract in both the neurogenic phase and the inflammatory phase; however, theophylline (an adenosine antagonist) completely blocked the effect in the neurogenic phase and significantly inhibited the effect in the inflammatory phase. These findings demonstrate that the ethanolic extract of C. erythrocarpos roots has both central and peripheral antinociceptive effect with possible involvement of adenosinergic mechanism.
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