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Articles by C.A. Fatimah
Total Records ( 5 ) for C.A. Fatimah
  Z.A. Zakaria , M.N. Somchit , H. Zaiton , A.M. Mat Jais , M.R. Sulaiman , W.O. Farah , R. Nazaratulmawarina and C.A. Fatimah
  The presence study was carried out to investigate on the possible antibacterial activity of methanol (MECO) and chloroform (CECO) extracts of Corchorus olitorius (Senaung betina) using the in vitro disc diffusion methods. The sterilized blank discs (6 mm diameter) was impregnated with 20 μL of the respective extract (in the concentration of 10,000; 20,000; 40,000 and 50,000 ppm) and tested against Corneybacterium diphtheria, Staphylococcus aureus (ATCC 25923), Bacillus cereus, Proteus vulgaris, Staphylococcus epidermidis, Kosuria rhizophila, Shigella flexneri, Escherichia coli (O 157), Aeromonas hydrophila and Listeria monocytogenes. The MECO and CECO, at all concentrations, were effective against C. diptheria and K. rhozophila with the latter also effective against S. aureus and B. cereus. At the concentration of 40,000 ppm and above, the MECO was effective only against S. aureus, B. cereus and S. epidermidis while the CECO was effective against S. epidermidis, S. flexneri and A. hydrophila. Based on this study, it was concluded that C. olitorius possesses antibacterial activity that is comparable to some of the standard antibiotics.
  Z.A. Zakaria , H.M. Khairi , M.N. Somchit , M.R. Sulaiman , A.M. Mat Jais , I. Reezal , N.N. Mat Zaid , S.N.Z. Abdul Wahab , N.S. Fadzil , M. Abdullah and C.A. Fatimah
  To determine on the antibacterial activity of the leaves and acute toxicity level of the leaves, tender leaves and rhizomes of Manihot esculenta var. Sri Pontian extracts. The chloroform (CME1) and ethanol (EME1) leaves extracts of M. esculenta (25, 50 and 100% concentrations) were tested against a selected groups of Gram positive and Gram negative bacteria using the disc diffusion method. On the other hand, the chloroform and ethanol leaves (CME2 and EME2), as well as the tender young leaves (CME3 and EME3) and rhizomes (CME4 and EME4), extracts of M. esculenta, (concentration ranging from 200 to 2600 ppm) were tested for their chronic toxicity level using the brine shrimp bioassay. CME1 was found to give positive antibacterial activity against L. monocytogenes, Vibrio cholerae, Shigella flexneri and Salmonella typhi while EME1 was effective against P. aeroginosa, C. diphtheria and V. cholerae. The results also showed that among the chloroform extracts, CME4 (LC50) = 413.9±51.6) possessed significantly (p<0.05) high toxicity followed by CME3 (LC50 = 496.2±33.1) and CME2 (LC50 = 532.9±22.9) while among the ethanol extracts, EME3 (LC50 = 344.7±33.9) was significantly (p<0.05) more toxic followed by EME2 (LC50 = 534.3±81.5) and EME4 (LC50 = 609.6±74.8). Overall, EME3 and CME4 were highly toxic than their counterpart (CME3 and EME4), respectively, while CME2 and EME2 did no show any discrepancy in their LD50 value. M. esculenta possess an antibacterial property and low toxicity level.
  Z.A. Zakaria , C.A. Fatimah , A.M. Mat Jais , H. Zaiton , E.F.P. Henie , M.R. Sulaiman , M.N. Somchit , M. Thenamutha and D. Kasthuri
  The present study was carried out to investigate on the possible antibacterial activity of aqueous (AEMC), methanol (MEMC) and chloroform (CEMC) extracts of Muntingia calabura using the in vitro disc diffusion methods. The sterilized blank discs (6 mm diameter) was impregnated with 20 μL of the respective extract (in the concentration of 10,000, 40,000, 70,000 and 100,000 ppm) and tested against Corneybacterium diphtheria, Staphylococcus aureus (ATCC 25923), Bacillus cereus, Proteus vulgaris, Staphylococcus epidermidis, Kosuria rhizophila, Shigella flexneri, Escherichia coli (O 157), Aeromonas hydrophila and Salmonella typhi. At all concentrations tested, the AEMC was effective against S. aureus and K. rhizophila while the MEMC was effective against S. flexneri, B. cereus, S. aureus, P. vulgaris, A. hydrophila, K. rhizophila. This activity was not observed with the CEMC. At the concentration of 40000 ppm and above, the AEMC exhibited significant antibacterial activity against C. dihptheriae, P. vulgaris, S. epidermidis and A. hydrophila; the MEMC was effective against C. diphtheriae and L. monocytogenes; and the CEMC was effective against S. aureus. Finally, we concluded that M. calabura possesses a potential antibacterial property that is comparable to the standard antibiotics used. The results also suggest the presence of more potent polar antibacterial compound.
  Z.A. Zakaria , A.M. Mat Jais , M.N. Somchit , M.R. Sulaiman and C.A. Fatimah
  The present study was carried out to elucidate some of the basic physical properties of the bioactive compounds responsible for Channa striatus antinociception. The aqueous extract of C. striatus was obtained after soaking the fish fresh fillet in the ratio of 1:2 (w/v) in chloroform: methanol (2:1; v:v) overnight. The extract, in the concentrations of 10, 50 and 100%, was subjected to the centrifugation-filtration process using the Millipore Ultrafree-CL low binding cellulose filters with different pore size (5,000, 10,000 and 30,000 dalton) prior to the abdominal constriction test in mice, respectively. Subsequently, the 100% concentration extract was also subjected to the analytical high performance liquid chromatography (using a Gilson 715 HPLC equipped with two slave 306 pumps and analytical reverse-phase Vydac C-18 column (10 μm, 0.46 x 25 cm) set at 40°C, with the flow rate of 0.5 mL min-1 absorbance at the wavelength of 220 nm was monitored by a wavelength UV detector; the eluant A was 100% methanol and eluant B was 80% methanol in dH2O) to establish its chromatogram profiles and the first fraction obtained was collected and subjected to the same antinocceptive assay. The non-filtered extract was found to exhibit a concentration-dependent antinociception (p<0.05). Except for the 30,000 dalton extract, the 5,000 and 10,000 dalton extracts antinociception were significantly different (p<0.05) from the non-filtered extract. Furthermore, the chromatogram profiles of C. striatus aqueous extract revealed the presence of four major fractions while the first fraction, prepared in the concentrations of 0.005, 0.05, 0.5 and 5 mg kg-1, was found to exhibit significantly (p<0.05) concentration-dependent antinociception. Based on the present data obtained, it is plausible to suggest that at least four types of bioactive compounds with molecular weight ranging from lower than 5,000 dalton as well as between 10,000 to 30,000 dalton presences in the aqueous extract of C. striatus.
  Z.A. Zakaria , M.N. Somchit , M.R. Sulaiman , A.M. Mat Jais and C.A. Fatimah
  The present study was carried out to determine the involvement of various receptor antagonists in and the effect of pH and enzymes on the recently reported antinociceptive activity of aqueous extract of Muntingia calabura leaves (MCAE) using the abdominal constriction test. The extract was prepared by soaking the dried powdered leaves of M. calabura in distilled water (dH2O) overnight and the supernatant obtained was considered as a stock solution with 100% concentration/strength. The MCAE, administered s.c. at the concentrations of 5, 50 and 100%, were found to show significant antinociceptive activity in a concentration-dependent manner. The 50% concentration MCAE was further used to study on the above mentioned parameters. The extract exhibited significant (p<0.05) decreased in activity when pre-treated (s.c.) against 10 mg kg-1 naloxonazine, 10 mg kg-1 pindolol and 5 mg kg-1 atropine, but not 10 mg kg-1 -funaltreaxamine, 10 mg kg-1 naltrindole, 10 mg kg-1 phenoxybenzamine, 10 mg kg-1 bicuculine or 5 mg kg-1 mecamylamine, respectively. The extract exhibited significant (p<0.05) increased in activity after pre-treatment at alkaline pH (pH 9 and 11) while maintaining the activity at the extreme acidic and alkaline conditions (pH 2 and pH 13), respectively. The extract activity was not changed after pre-treatment against -amylase, protease, lipase or their combination, when compared to the dH2O-pre-treated group, respectively. Based on the results, we conclude that the M. calabura leaves peripheral antinociception involved, at least in part, activation of -opioid, -adrenergic and muscarinic receptors and resist the effect of extreme acidic and alkaline conditions as well as various enzymes.
 
 
 
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