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Articles by C. Tan
Total Records ( 2 ) for C. Tan
  Y. Yan , J. Huang , B. Chen , Y. Liu and C. Tan
  Radio bursts with fine structures in decimetric-centimetric wave range are generally believed to manifest the primary energy release process during flare/CME events. By spectropolarimeters in 1-2 GHz, 2.6-3.8 GHz, and 5.2-7.6 GHz at NAOC/Huairou with very high temporal (1.25-8 ms) and spectral (4-20 MHz) resolutions, the zebra patterns, spikes, and new types of radio fine structures with mixed frequency drift features are observed during several significant flare/CME events. In this paper we will discuss the occurrence of radio fine structures during the impulsive phase of flares and/or CME initiations, which may be connected to the magnetic reconnection processes.
  S. C. Lim , D. Q. Liying , W. C. Toy , M. Wong , L. Y. Yeoh , C. Tan , D. Lau , C. Tan , T. Subramaniam and C. F. Sum
  Objective  A substantial proportion of diabetic nephropathy individuals are non-albuminuric. Using a proteomic approach, we searched for novel urinary biomarkers.

Methods  We studied three groups (n = 6 per group) of males with Type 2 diabetes: (1) normal renal function; (2) classical diabetic nephropathy (urinary albumin-creatinine ratio > 1000 mg/g and glomerular filtration rate < 60 ml/min.1.73 m2) and (3) non-albuminuric diabetic nephropathy (glomerular filtration rate < 60 ml/min.1.73 m2 and urinary albumi-creatinine ratio < 30 mg/g). We used two-dimensional fluorescence differential gel electrophoresis, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry peptide identification and western blot validation in the study.

Results  Sixty protein spots were differentially abundant between the non-albuminuric and macro-albuminuric subjects (> 2.5-fold, P < 0.05). In the non-albuminuric subjects, in addition to previously reported α1-microglobulin, the next most interesting spot (upregulated 3.44-fold, P = 0.0026) was human zinc-α2-glycoprotein, a novel adipose-cytokine associated with glomerular injury. This was confirmed by western blot and replicated in female diabetic nephropathy subjects.

Conclusions  From our preliminary results, human zinc-α2-glycoprotein may be a novel urinary biomarker for non-albuminuric diabetic nephropathy.

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