Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by C. Suresh
Total Records ( 2 ) for C. Suresh
  M. Saminathan , R.B. Rai , K. Dhama , G.J. Ranganath , V. Murugesan , K. Kannan , S. Pavulraj , A. Gopalakrishnan and C. Suresh
  Mammary tumours rank second as the most common neoplasms in dogs after skin tumours, whereas in women the most common cause of cancer-related deaths is breast cancer. N-Methyl-N-Nitrosourea (NMU) is a highly specific mammary gland carcinogen which directly act and does not require metabolic activation. In the present study, NMU at the dose rate of 50 mg kg-1 body weight was used intra-peritoneally for the induction of mammary tumour. The first palpable tumour appeared on 70th day post carcinogen injection and subsequently, most of the tumours were developed around 18-20th week. During 28 weeks of experimental period, the tumour incidence was 82.86% (29/35). The tumour frequency was found to be 4.7±0.33 tumours and the average latency period was 107±4.1 days. The average tumour volume was found to be 69±8.8 cm3. Equally, 50% of mammary tumours appeared on the right (22/44) and left (22/44) mammary gland chain. Region wise, 81.82% (36/44) of the tumours appeared on abdominal-inguinal mammary glands and 18.18% (8/44) on the cervical thoracic mammary glands. A total of 44 mammary tumours were diagnosed in which 88.64% (39/44) were malignant and 11.36% (5/44) were benign. Among the malignant tumours, 33.33% (13/39) were non-invasive and 66.67% (26/39) were invasive. The average values of mitotic index, Proliferating Cell Nuclear Antigen (PCNA), Vascular Endothelial Growth Factor (VEGF) and Platelet Endothelial Cell Adhesion Molecule (PECAM-1) in NMU induced mammary tumours were found to be 4.5±0.46/hpf, 77±2.6, 16.2±0.86 and 15±0.69, respectively. The present study for the first time demonstrated the expression of VEGF and PECAM-1/CD-31 proteins in NMU induced mammary tumours.
  M.A. Ravichandran , M. Saminathan , A. Arun Prince Milton , K. Dhama , C. Suresh , K. Jeeva and S.K. Misra
  Cytogenetic studies in domestic animals are gaining more importance because of their genetic implications to breeding programmes. The present study describes the chromosome profile and morphometric characteristics of Garole and Bonpala sheep and comparison of chromosomes between males, females and between breeds. The Karyotype revealed diploid chromosome number of 54 (2n) in both breeds and sexes. The first three pairs of autosomes were bi-armed, submetacentric and remaining 23 pairs were acrocentric. The X-chromosome was acrocentric and largest and Y-chromosome was the smallest, biarmed and metacentric. The morphometric analysis showed significant variation in mean relative length of 13th chromosome pair of Garole and Bonpala males and significant variation in the arm ratio of 2nd chromosome pair of females and variation also noticed in almost all the pairs of chromosomes but not up to the level of significance. The mean relative length of autosomes of Garole and Bonpala male ranged from 1.39±0.05 to 11.45±0.15 and 1.48±0.06 to 11.69±0.25 percentage, respectively. The mean relative length of X-chromosome of the males was 5.66±0.15 and 5.83±0.17, respectively while the Y-chromosome length was 1.20±0.02 and 1.27±0.06, respectively. The mean relative length of autosomes of the females ranged from 1.43±0.06 to 10.80±0.20 and 1.42±0.04 to 11.42±0.36, respectively. The mean relative length of X-chromosome of Garole and Bonpala female was 5.51±0.13 and 5.61±0.15, respectively. The mean arm ratio of first 2 pairs of autosomes of Garole male was higher than Bonpala male while the 3rd pair was higher in Bonpala males. The mean arm ratio of first 3 pairs of autosomes of Garole female was higher than Bonpala female. The present study for the first time compares the cytogenetic profile between Garole and Bonpala sheep breeds.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility