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Articles by C. Sharma
Total Records ( 2 ) for C. Sharma
  A. Hussain , S. Sasidharan , T. Ahmed , M. Ahmed and C. Sharma
  Cervical cancer is the second most common carcinoma in the world among women and is highly chemoresistant and radio resistant, often resulting in local treatment failure. For locally advanced disease, radiation is combined with low-dose chemotherapy; however, this modality often leads to severe toxicity. Prevention of cancer through dietary intervention recently has received an increasing interest, and dietary agents have become not only important potential chemopreventive, but also therapeutic agents when combined with chemotherapy or radiotherapy. In this study, we observed that gemcitabine was highly cytotoxic to both cancer and normal cells while clove extract (0.7-8 mg mL-1) was found to be comparatively more cytotoxic towards cancer cells. Notably, combination of low dose gemcitabine and ethanolic clove extract (2 and 3 mg mL-1) had more pronounced cytotoxic effect on cancer cells than single modalities. It is noteworthy that use of clove extract increased the efficacy of gemcitabine and importantly, it was found to be minimally toxic to normal cells. Together, these results suggest a novel mechanism may be involved in the synergistic effect of this combination.
  Delhi is the most urbanized city in India. Inventory estimates for the emissions of greenhouse gases and other pollutants like CO2, CO, NOx, and volatile organic compound from transport sector in Delhi, has been developed using bottom up approach provided by Intergovernmental panel on climate change (IPCC-1996). The impacts of policy option in transport sector like introduction of Compressed Natural Gas for public transport in Delhi and introduction of Euro-1 norms for vehicles have also been estimated. The emission inventory reveals that total emission of pollutants from different categories vehicles have increased during the period 1990-2000. For example, the CO2 emission (1000, tones) from gasoline driven vehicle (MC/SC) in Delhi has increased from 766 in 1990-91 to 1187 in 1999-00. The diesel driven vehicles Light commercial vehicles in Delhi has contributed to 577 CO2 in 1990-91, which increased to 9779 in 1999-00. For other pollutants also, which have been estimated here, an increase in total emission from gasoline and diesel driven vehicles has been observed during this 1990-2000 periods. This study shows that the over all contribution of pollutants in the total emissions from gasoline and diesel driven vehicles have increased in Delhi during this period. The present study also shows that the implementation of Euro-1 in 2000 in Delhi has resulted in the decrease of total emission of CO, HC, NOx, and volatile organic compound for all the classes of vehicle for which the revised vehicle emissions norms were implemented. However this decrease in emission has become inefficient due to increase in vehicle population.
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