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Articles by C. Gao
Total Records ( 2 ) for C. Gao
  J.S. Chen , R.F. Zhu , Y.X. Zhang , S. Chen , C. Gao and D.G. Li
  A defoliation experiment was conducted on a Leymus chinensis-dominated steppe to provide guidelines of grazing management and restoration of degraded grasslands. There were five defoliation treatments: CK (non-defoliation as control); LD (Light Defoliation, cut 12 cm aboveground level); MD (Medium Defoliation, 8 cm); HD (Hard Defoliation, 4 cm) and SD (Severe Defoliation, 2 cm). Results showed that HD and SD defoliation significantly decreased the belowground biomass. Defoliation increased plant species diversity but decreased biomass of L. chinensis significantly. The biomass of L. chinensis under LD was lower than that in control indicating L. chinensis was highly sensitive to defoliation. It is necessary in this area that grazing should be restricted to a level of light defoliation to prevent loss of plant productivity.
  C. Gao , J. Huan , J. Tang and W. Li
  Although previous studies have demonstrated that stromal-derived factor-1 (SDF-1) played a key role in chronic graft dysfunction (CGD), the precise mechanisms underlying this process are not clear. In this study, SDF-1 was injected into keratinocyte stem cells (KSCs) which were isolated and purified from neonatal C57BL/6 (H-2b) mice. Adenylyl cyclase (AC) activity of KSCs was measured and expressions of the human major histocompatibility complex (MHC) class I chain-related antigens A and B (MICA, MICB) detected by immunofluorescence. Cultured KSCs were negative for IA/IE MHC class II molecules by immunofluorescence, indicating the absence of any contamination with Langerhans cells and certifying the purity of KSCs. Over a 7-day culture period, SDF-1 up-regulated AC activity to 2.783 ± 0.799, which was higher than that of the control group (1.290 ± 0.476; P < .01). Immunostaining showed that KSCs expressed increased amounts of MICA protein (0.790 ± 0.134 versus 0.200 ± 0.022; P < .01) and MICB protein (0.610 ± 0.832 versus 0.230 ± 0.016; P < .01). Mixed lymphocyte reaction assays showed that KSCs cultured with SDF-1 injection for 7 days stimulated allogeneic T-cell proliferation. The data indicated that SDF-1 may accelerate the ultimate rejection of allogeneic keratinocytes by enhancing MIC through the AC signal pathway.
 
 
 
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