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Articles by C. Chellaram
Total Records ( 7 ) for C. Chellaram
  C. Chellaram , T. Prem Anand , N.R. Shailaja and D. Kesavan
  The plants, animals and microorganisms of the marine environment with their wide range of chemical diversity are still an unexplored resource for the development of new agro-chemical agents. Works related to the herbicidal activity of the marine organisms are too scanty. Compared to the search for new pharmaceutical compounds, very little effort has been devoted to the exploration of agrochemical compounds from marine natural products. In the present study, the herbicidal activity of the crude extracts and partial purified fractions of Trochus tentorium was assayed using the duckweed, Lemna minor L. following a bench top bioassay. The crude acetone extract of T. tentorium decayed the fronds of Lemna plants at the concentration of 1000 mg mL-1 on the 4th day, while the results of same concentration of ethyl acetate, dichloromethane and methanol extracts showed decay of the plants on the 5th day of the experiment. This study reveals that the column-purified acetone fraction of the gastropod was able to decay L. minor to a better degree in comparison with the crude extracts. Hence, from the present study, it was noted that not only the 100% acetone fractions but also the 20:80 hexane: methanol and 80:20 acetone: methanol fractions showed a higher degree of activity against L. minor.
  C. Chellaram , R.S. Sreenivasan , S. Jonesh , T.P. Anand and J.K.P. Edward
  To test the antibacterial effect of the extracts of Drupa margariticola obtained using low to high polar solvents, like ethyl acetate, dichloromethane, acetone and methanol. Partial purification of the active crude extract was carried out using column chromatography employing a step gradient solvent system. A maximum inhibition of 7 mm against E. coli was shown by the 100% acetone column purified fractions of D. margariticola at a concentration of 0.125 mg. Minimum Inhibitory Concentration values were found to be lower for the 100% acetone fraction for pathogens, E. coli (0.05 mg), Klebsiella pnuemoniae (0.05 mg), Pseudomonas aerogenosa (0.07 mg) and Streptococcus pnuemoniae (0.07 mg). Thus 100% acetonated fraction of the extract of D. margariticola was considered as potent antibacterial compounds against some human pathogens. The antibacterial potential of the mollusc, Drupa maragariticola becomes a corner stone for the future development of novel biologically active compounds.
  C. Chellaram and J.K. Patterson Edward
  The extract of gastropod, Drupa margariticola tested for their analgesic assets using chemical (acetic acid) induced and hot plate method on Swiss mice model showed promising results. One hundred percent column purified extracts of the D. margariticola (25 and 100 mg kg -1 p.o.) exhibited significant (p<0.001) writhing inhibition of 65 and 78.57%, respectively against acetic acid induced abdominal constrictions. The result of hot plate study, in the difference between the mean reaction time and increased percentage of jump response of test animals in the treated groups, control and standard groups were statistically significant (p<0.001). At 30 min, the mean reaction time for extracts (50 mg kg -1 p.o.) group was 6.67 ±1 sec, when compared to control group (2.67 ±0.52 sec) and pentazocine treated groups (11.5 ±1.22 sec) for 100 mg kg -1 p.o. These facts suggest that the 100% acetone fraction of the D. margariticola was shown the strongest analgesic action. The important results obtained in present study were central and peripheral analgesic activities demonstrated by the inhibitory action on the acetic acid induced writhings and hot plate models. The hot plate method was found to be suitable in the evaluation of centrally acting analgesic action but not for peripherally acting analgesic action.
  C. Chellaram , S. Jonesh , T. Prem Anand and J.K.P. Edward
  The aim of this study, the coral reef associated mollusc Drupa margariticola was screened for their insecticidal activity against a dreadful rice pest Sitophilus oryzae, The insecticidal activity of the crude and partially purified extracts of D. margariticola was tested using contact bioassay by the modified method. The extracts of acetone, ethyl acetate and dichloromethane caused 100% (10), 80.67% (8.67±1.25) and 80.0% (8±0.82) mortality respectively against S. oryzae at a concentration of 50 mg mL-1. The 100% acetone column purified fractions of extracts was found cause 100% at a concentration of 20 mg. The ED50 value of crude and column purified acetone extracts of D. margariticola was found to be lower 21.08 and 4.09 mg mL-1, respectively. The extract of D. margariticola screened for insecticidal activity clearly shows that the extract of acetone may possess some biologically active compounds. The exact route of entry is doubtful, which, in future can be cleared with studies on the mode of action of the extract tested.
  C. Chellaram and A. Alex John
  Marine organisms continue to be a huge source to produce unique and potential bioactive compounds that cure deadly disease. This research investigates the herbicidal properties of bacteria isolated from surface of the coral, Junceella juncea (Pallas, 1766). Two hundred and thirty four different bacterial strains were isolated from the coral from Tuticorin coast, Gulf of Mannar region, south east coast of India. The strain WP3 was found to prove excellent herbicidal property when tested against Lemna minor. The 16S rRNA sequencing and phylogenetic identification shows that the stain WP3 was identified to fell under the genera Bacillus. The assay was carried out for crude extract and column purified extract. Mass spectrophotometry (MALDI-TOF) analysis has shown that the mass of the molecules ranged from 1148-1729 Da. Thus the marine bacteria isolated from corals are a potential source of novel bioactive agents and other natural products.
  S. Anbuselvi , C. Chellaram , S. Jonesh , L. Jayanthi and J.K.P. Edward
  Whole body meats of mollusc, Trochus tentorium was extracted with four solvents such as acetone, ethyl acetate, dichloromethane and methanol. Maximum antibacterial inhibition zone was exhibited from acetone crude extract of T. tentorium against human pathogen (Streptococcus pneumoniae 8 mm). The 100% column purified acetone fraction of T. tentorium showed higher activity against human pathogens like Klebsiella pneumoniae (7 mm). The minimal inhibitory concentration of the 100% acetone fraction of T. tentorium was found to be lower for the pathogens, E. coli (0.08 mg), Streptococcus pnuemoniae (0.08 mg), Staphylococcus aureus (0.09 mg) and Vibrio cholerae (0.09 mg), hence 100% acetone fraction of the extract of T. tentorium was deemed as potent bioactive compounds against those pathogens.
  C. Chellaram , P. Raja , A. Alex John and S. Krithika
  Aim of this study was to evaluate the antagonistic potential of epibiotic bacteria from seaweeds, Ulva lactuca, Dictyota dichotoma and Padina tetrastromatica against some potent human pathogens. The epibiotic bacteria of Ulva lactuca shows higher level of inhibition properties than the other species. The strain UL1 shows broad spectrum inhibitory activity against 7 pathogens. The inhibitory level of epibiotic bacteria ranged from low to moderate activity. The present investigation suggests that the epibiotic bacteria are good source for the isolation of antibacterial compounds of biomedical importance. The compounds can further be purified and can used to save mankind from dreadful diseases.
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