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Articles by C. S Chen
Total Records ( 4 ) for C. S Chen
  C. H Ko , J. Y Yen , C. S Chen , Y. C Yeh and C. F. Yen

Objectives  To evaluate the predictive values of psychiatric symptoms for the occurrence of Internet addiction and to determine the sex differences in the predictive value of psychiatric symptoms for the occurrence of Internet addiction in adolescents.

Design  Internet addiction, depression, attention-deficit/hyperactivity disorder, social phobia, and hostility were assessed by self-reported questionnaires. Participants were then invited to be assessed for Internet addiction 6, 12, and 24 months later (the second, third, and fourth assessments, respectively).

Setting  Ten junior high schools in southern Taiwan.

Participants  A total of 2293 (1179 boys and 1114 girls) adolescents participated in the initial investigation.

Main Exposure  The course of time.

Main Outcome Measure  Internet addiction as assessed using the Chen Internet Addiction Scale.

Results  Depression, attention-deficit/hyperactivity disorder, social phobia, and hostility were found to predict the occurrence of Internet addiction in the 2-year follow-up, and hostility and attention-deficit/hyperactivity disorder were the most significant predictors of Internet addiction in male and female adolescents, respectively.

Conclusions  These results suggest that attention-deficit/hyperactivity disorder, hostility, depression, and social phobia should be detected early on and intervention carried out to prevent Internet addiction in adolescents. Also, sex differences in psychiatric comorbidity should be taken into consideration when developing prevention and intervention strategies for Internet addiction.

  J Zhang , L Villacorta , L Chang , Z Fan , M Hamblin , T Zhu , C. S Chen , M. P Cole , F. J Schopfer , C. X Deng , M. T Garcia Barrio , Y. H Feng , B. A Freeman and Y. E. Chen

Nitro-oleic acid (OA-NO2) is a bioactive, nitric-oxide derived fatty acid with physiologically relevant vasculoprotective properties in vivo. OA-NO2 exerts cell signaling actions as a result of its strong electrophilic nature and mediates pleiotropic cell responses in the vasculature.


The present study sought to investigate the protective role of OA-NO2 in angiotensin (Ang) II–induced hypertension.

Methods and Results:

We show that systemic administration of OA-NO2 results in a sustained reduction of Ang II–induced hypertension in mice and exerts a significant blood pressure lowering effect on preexisting hypertension established by Ang II infusion. OA-NO2 significantly inhibits Ang II contractile response as compared to oleic acid (OA) in mesenteric vessels. The improved vasoconstriction is specific for the Ang II type 1 receptor (AT1R)-mediated signaling because vascular contraction by other G-protein–coupled receptors is not altered in response to OA-NO2 treatment. From the mechanistic viewpoint, OA-NO2 lowers Ang II–induced hypertension independently of peroxisome proliferation-activated receptor (PPAR) activation. Rather, OA-NO2, but not OA, specifically binds to the AT1R, reduces heterotrimeric G-protein coupling, and inhibits IP3 (inositol-1,4,5-trisphosphate) and calcium mobilization, without inhibiting Ang II binding to the receptor.


These results demonstrate that OA-NO2 diminishes the pressor response to Ang II and inhibits AT1R-dependent vasoconstriction, revealing OA-NO2 as a novel antagonist of Ang II–induced hypertension.

  A Moran , D Gu , D Zhao , P Coxson , Y. C Wang , C. S Chen , J Liu , J Cheng , K Bibbins Domingo , Y. M Shen , J He and L. Goldman

Background— The relative effects of individual and combined risk factor trends on future cardiovascular disease in China have not been quantified in detail.

Methods and Results— Future risk factor trends in China were projected based on prior trends. Cardiovascular disease (coronary heart disease and stroke) in adults ages 35 to 84 years was projected from 2010 to 2030 using the Coronary Heart Disease Policy Model–China, a Markov computer simulation model. With risk factor levels held constant, projected annual cardiovascular events increased by >50% between 2010 and 2030 based on population aging and growth alone. Projected trends in blood pressure, total cholesterol, diabetes (increases), and active smoking (decline) would increase annual cardiovascular disease events by an additional 23%, an increase of approximately 21.3 million cardiovascular events and 7.7 million cardiovascular deaths over 2010 to 2030. Aggressively reducing active smoking in Chinese men to 20% prevalence in 2020 and 10% prevalence in 2030 or reducing mean systolic blood pressure by 3.8 mm Hg in men and women would counteract adverse trends in other risk factors by preventing cardiovascular events and 2.9 to 5.7 million total deaths over 2 decades.

Conclusions— Aging and population growth will increase cardiovascular disease by more than a half over the coming 20 years, and projected unfavorable trends in blood pressure, total cholesterol, diabetes, and body mass index may accelerate the epidemic. National policy aimed at controlling blood pressure, smoking, and other risk factors would counteract the expected future cardiovascular disease epidemic in China.

  C. H Tzeng , C. S Chen , P. C Tang and T. S. Chiu

Tzeng, C-H., Chen, C-S., Tang, P-C., and Chiu, T-S. 2009. Microsatellite and mitochondrial haplotype differentiation in blue mackerel (Scomber australasicus) from the western North Pacific. – ICES Journal of Marine Science, 66: 816–825.

Blue (Scomber australasicus) and chub mackerel (Scomber japonicus) occur sympatrically in the western North Pacific. Blue mackerel were previously classified as a subspecies of S. japonicus based on morphological similarities. The practical management unit for blue mackerel is contentious owing to incomplete resolution by biological analyses. We used rapidly evolving microsatellites and slow-changing mitochondrial cytochrome b (mtCyt-b) markers to examine the phylogeographic relationships of the two species across four major hydrographic regions of the western North Pacific. Genetic variability was high in each hydrographic region and in the putative species unit, and Hardy–Weinberg equilibrium tests confirmed that blue and chub mackerel are separate genetic components. Population genetic and multiple-dimensional scaling analyses of the genotypes indicated clear genetic differences, and phylogenetic analyses of the mtCyt-b haplotypes showed a level of genetic divergence (FST = 0.038, p < 0.001) consistent with separation of the two species. Based on the coalescence theory, the difference in mtCyt-b genes was small, indicating incipient speciation between blue and chub mackerel, with a diversification time of 1.9 million years ago (mya) during the Pleistocene when the East China Sea (ECS) and the South China Sea (SCS) were separated physically. Significant differences between populations of blue mackerel in the ECS and SCS were also found. Our findings confirm that blue mackerel is a valid biological species and that its populations in the ECS and SCS should be considered separate fishery stocks and conservation units for management.

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