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Articles by C. C Huang
Total Records ( 3 ) for C. C Huang
  W. C Chao , C. C Huang , P. H Chang , Y. L Chen , C. W Chen and T. J. Lee

Objective  To evaluate hospitalization rates and duration of surgery associated with transnasal endoscopic marsupialization compared with sublabial excision in treating nasolabial cysts.

Design  Retrospective clinical series.

Setting  Large urban community hospital.

Patients  Consecutive sample of 57 patients with nasolabial cysts treated from January 1, 2000, to February 29, 2008.

Interventions  Sublabial excision in 23 patients (sublabial group) and transnasal endoscopic marsupialization in 34 patients (transnasal group). Among 57 patients, 47 underwent preoperative computed tomography.

Main Outcome Measures  History, clinical presentation, preoperative condition, histopathologic findings, treatment, complications, and outcomes.

Results  The mean duration of surgery was 91.3 minutes in the sublabial group and 29.5 minutes in the transnasal group (P = .003). The hospitalization rate was 100% (23 of 23) in the sublabial group and 59% (20 of 34) in the transnasal group (P < .001). The medical costs were significantly lower in the transnasal group than in the sublabial group (P = .002). The follow-up period ranged from 6 to 85 months. Neither group of patients experienced any major complications or recurrences during the follow-up period.

Conclusion  Transnasal endoscopic marsupialization is an effective treatment for nasolabial cysts, is less costly, and has fewer complications than sublabial excision.

  J. N Al Swiahb , C. C Huang , F. M Fang , H. C Chuang , H. Y Huang , S. D Luo , C. H Chen , C. M Chen and C. Y. Chien

Objective  To evaluate the prevalence of human papillomavirus (HPV) and the prognostic significance of epidermal growth factor receptor (EGFR), p53, and p16 among patients with oropharyngeal carcinoma.

Design  Retrospective study.

Setting  Academic Institute of Otolaryngology, Kaohsiung, Taiwan.

Patients  Two hundred seventy-four patients who were diagnosed as having oropharyngeal carcinoma underwent testing for the presence of the HPV genome in the nuclei of their tumor cells from January 1, 1992, through March 31, 2008.

Interventions  The HPV genome was detected by performing polymerase chain reaction–based assays and in situ hybridization on tumor tissue from paraffin blocks. Immunohistochemistry staining for p16, p53, and EGFR was also performed.

Main Outcome Measures  We used the Fisher exact test to evaluate the correlation between the clinicopathological variables and the presence of HPV in tumor cells. Survival analysis was based on the Kaplan-Meier method.

Results  We detected HPV in 45 of the 274 patients (16.4%); of these, HPV-16 and -18 were identified in 42 (93.3%) of the HPV-positive tumors. The HPV-positive oropharyngeal cancers were more likely to occur in females, nonsmoking individuals, and those who did not chew betel quid. The HPV-positive tumors significantly expressed p16 and were inversely associated with EGFR and p53 expression (all, P < .001). In addition, patients with tumor tissue that was positive for HPV (P = .008) and had negative expression of EGFR (P = .01), low expression of p53 (P = .01), and high expression of p16 (P = .04) had a better prognosis.

Conclusion  Our results suggest that HPV, EGFR, p53, and p16 are useful biomarkers in predicting the clinical outcomes of oropharyngeal cancer.

  C. C Huang , M Fornage , D. M Lloyd Jones , G. S Wei , E Boerwinkle and K. Liu

Background— Mutations of PCSK9 are associated cross-sectionally with plasma low-density lipoprotein cholesterol (LDL-C) levels, but little is known about their longitudinal association with LDL-C levels from young adulthood to middle age.

Methods and Results— We investigated the associations of 6 PCSK9 variants with LDL-C over 20 years in 1750 blacks and 1828 whites from the Coronary Artery Risk Development In Young Adults study. Generalized estimating equations were used to assess longitudinal differences in LDL-C levels between genotype categories. For blacks, LDL-C levels at age 18 were significantly lower (P<0.001) among those with 3 genetic variants (L253F, C679X, and Y142X; 81.5 mg/dL) and A443T (95.5 mg/dL) compared with noncarriers (109.6 mg/dL). The difference in LDL-C levels from noncarriers tended to widen for those with the 3 variants only, by 0.24 mg/dL per year of age (P=0.14). For whites with the R46L variant, compared with noncarriers, LDL-C levels at age 18 were significantly lower (84.4 mg/dL versus 100.9 mg/dL; P<0.001), and the increase in LDL-C with age was similar to noncarriers. The 3 genetic variants and the A443T variant in black men were associated with lower carotid intima-media thickness and lower prevalence of coronary calcification measured at ages 38 to 50.

Conclusions— Our results suggest that participants with several genetic variants of PCSK9 have persistently lower serum LDL-C levels than noncarriers from ages 18 to 50. Such long-term reduction in LDL-C levels is associated with reduced subclinical atherosclerosis burden in black men.

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