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Articles by C Tian
Total Records ( 2 ) for C Tian
  X Li , C Dong , S Shi , G Wang , Y Li , X Wang , Q Shi , C Tian , R Zhou , C Gao and X. Dong
 

Prion protein (PrP) is considered to associate with microtubule and its major component, tubulin. In the present study, octarepeat region of PrP (PrP51–91) was expressed in prokaryotic-expressing system. Using GST pull-down assay and co-immunoprecipitation, the molecular interaction between PrP51–91 and tubulin was observed. Our data also demonstrated that PrP51–91 could efficiently stimulate microtubule assembly in vitro, indicating a potential effect of PrP on microtubule dynamics. Moreover, PrP51–91 was confirmed to be able to antagonize Cu2+-induced microtubule-disrupting activity in vivo, partially protecting against Cu2+ intoxication to culture cells and stabilize cellular microtubule structure. The association of the octarepeat region of PrP with tubulin may further provide insight into the biological function of PrP in the neurons.

  C Tian , J Tan , X Wu , W Ye , X Liu , D Li and H. Yang
 

To describe the variation in bacterioplankton diversity within a large hypertrophic freshwater lake, as well as changes in the diversity that occurred with time, PCR- (denaturing gradient gel electrophoresis) DGGE was utilized to study water samples collected from Lake Taihu in China. To accomplish this, water samples were collected from different locations and during different months. The trophic status of these sampling sites ranged from eutrophic to hypertrophic. Cluster and multidimensional scaling analyses revealed that the temporal transition in the diversity of the bacterioplankton occurred primarily in response to a cyanobacterial bloom, and that all samples could be divided into normal-bloom, peak-bloom and winter period groups. Spatial differences in the bacterial diversity were also detected among the three sampling sites, with diversity being found to be strongly correlated with the gradient of the trophic status of the three sampling sites. In addition, these temporal and spatial changes could be characterized by several specific DGGE bands. The results were further analyzed by canonical correspondence analysis, which revealed that the bacterioplankton diversity of Lake Taihu was primarily associated with temperature, pH, total nitrogen (TN), total phosphorus (TP) and dissolved oxygen. Of these factors, TN and TP were only shown to be significant influencing factors at Wuxi, which had the highest trophic level.

 
 
 
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