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Articles by C Gallo
Total Records ( 2 ) for C Gallo
  N Zanou , G Shapovalov , M Louis , N Tajeddine , C Gallo , M Van Schoor , I Anguish , M. L Cao , O Schakman , A Dietrich , J Lebacq , U Ruegg , E Roulet , L Birnbaumer and P. Gailly
 

Skeletal muscle contraction is reputed not to depend on extracellular Ca2+. Indeed, stricto sensu, excitation-contraction coupling does not necessitate entry of Ca2+. However, we previously observed that, during sustained activity (repeated contractions), entry of Ca2+ is needed to maintain force production. In the present study, we evaluated the possible involvement of the canonical transient receptor potential (TRPC)1 ion channel in this entry of Ca2+ and investigated its possible role in muscle function. Patch-clamp experiments reveal the presence of a small-conductance channel (13 pS) that is completely lost in adult fibers from TRPC1–/– mice. The influx of Ca2+ through TRPC1 channels represents a minor part of the entry of Ca2+ into muscle fibers at rest, and the activity of the channel is not store dependent. The lack of TRPC1 does not affect intracellular Ca2+ concentration ([Ca2+]i) transients reached during a single isometric contraction. However, the involvement of TRPC1-related Ca2+ entry is clearly emphasized in muscle fatigue. Indeed, muscles from TRPC1–/– mice stimulated repeatedly progressively display lower [Ca2+]i transients than those observed in TRPC1+/+ fibers, and they also present an accentuated progressive loss of force. Interestingly, muscles from TRPC1–/– mice display a smaller fiber cross-sectional area, generate less force per cross-sectional area, and contain less myofibrillar proteins than their controls. They do not present other signs of myopathy. In agreement with in vitro experiments, TRPC1–/– mice present an important decrease of endurance of physical activity. We conclude that TRPC1 ion channels modulate the entry of Ca2+ during repeated contractions and help muscles to maintain their force during sustained repeated contractions.

  P Sharan , C Gallo , O Gureje , E Lamberte , J. J Mari , G Mazzotti , V Patel , L Swartz , S Olifson , I Levav , A de Francisco , S Saxena and the World Health Organization Global Forum for Health Research Mental Health Research Mapping Pro
 

Background

Studies suggest a paucity of and lack of prioritisation in mental health research from low- and middle-income (LAMI) countries.

Aims

To investigate research priorities in mental health among researchers and other stakeholders in LAMI countries.

Method

We used a two-stage design that included identification, through literature searches and snowball technique, of researchers and stakeholders in 114 countries of Africa, Asia, Latin America and the Caribbean; and a mail survey on priorities in research.

Results

The study identified broad agreement between researchers and stakeholders and across regions regarding research priorities. Epidemiology (burden and risk factors), health systems and social science ranked highest for type of research. Depression/anxiety, substance use disorders and psychoses; and children and adolescents, women, and people exposed to violence/trauma were prioritised among the disorders and population groups respectively. Important criteria for prioritising research were burden of disease, social justice, and availability of funds. Stakeholder groups differed in the importance they gave to the personal interest of researchers as a criterion for prioritising research. Researchers’ and stakeholders’ priorities were consistent with burden of disease estimates, however suicide was underprioritised compared with its burden. Researchers’ and stakeholders’ priorities were also largely congruent with the researchers’ projects.

Conclusions

The results of this first ever conducted survey of researchers and stakeholders regarding research priorities in mental health suggest that it should be possible to develop consensus at regional and international levels regarding the research agenda that is necessary to support health system objectives in LAMI countries.

 
 
 
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