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Articles by C Bottomley
Total Records ( 1 ) for C Bottomley
  C Bottomley , I Nazareth , F Torres Gonzalez , I Svab , H. I Maaroos , M. I Geerlings , M Xavier , S Saldivia and M. King


Factors associated with depression are usually identified from cross-sectional studies.


We explore the relative roles of onset and recovery in determining these associations.


Hazard ratios for onset and recovery were estimated for 39 risk factors from a cohort study of 10 045 general practice attendees whose depression status was assessed at baseline, 6 and 12 months.


Risk factors have a stronger relative effect on the rate of onset than recovery. The strongest risk factors for both onset and maintenance of depression tend to be time-dependent. With the exception of female gender the strength of a risk factor’s effect on onset is highly predictive of its impact on recovery.


Preventive measures will achieve a greater reduction in the prevalence of depression than measures designed to eliminate risk factors post onset. The strength of time-dependent risk factors suggests that it is more productive to focus on proximal rather than distal factors.

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