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Articles by Boyang Yu
Total Records ( 3 ) for Boyang Yu
  Boyang Yu , Fenhua Luo , Taodi Liu , Daiyan Liu , Linhong Liu , Yan Zhang and Yingji Wu
  Successful spermatogonial stem cells transplantation is largely dependent on the preparation of the recipient. In the present study, to acquire more efficient rat recipients, the response of pregnant female rats to treatment with 7.5-12.5 mg busulfan per kg of body weight was determined in terms of the birth rate, survival rate, body weight, testicular mass, histology, expression of certain germ cell genes as measured by real time PCR and fertility rate of male offspring. The analysis suggested that a dosage of 10 mg busulfan per kg administered to pregnant female rats at 13.5 day post pregnancy effectively prepares male pups to be recipients because it leads to the maximal deletion of endogenous spermatogonial stem cells with minimal effects on the recipientsí health.
  Zhihong Lin , Zhibin Xiao , Danni Zhu , Yongqing Yan , Boyang Yu and Qiujuan Wang
  Herb formula FBD is composed of fu ling [or poria, or the sclerotium of the fungus of Poria cocos (Schw.) Wolf (Polyporaceae)], bai zhu [white atractylodes rhizome, or the rhizome of Atractylodes macrocephala Koidz.(Compositae)], and dang gui [or dong quai, Chinese angelica root, or the root of Angelica sinensis (Oliv.) Diels (Umbelliferae)], the three Chinese medicinal plants used traditionally to improve cognitive disorders. The present study aimed to observe the effects of dual doses of aqueous extracts of FBD (200 and 600mg/kg) administered orally for 6 days on memory deficit induced by scopolamine, 4mg/kg intraperitoneally (i.p.) in male imprinting control region (ICR) mice. Aqueous extracts of FBD markedly ameliorated scopolamine induced memory deficit in passive step-through avoidance test and passage water maze test, significantly inhibited acetylcholinesterase (AChE) activity in cortex and hippocampus, and circulating butyrylcholinesterase activity. Moreover, cortical AChE activity in vitro was suppressed in a dose-dependent manner by aqueous extracts of FBD at 50–200 μg crude herb/mL, in which dang gui extract exerted a stronger anti-AChE activity than that of fu ling or bai zhu. In contrast, no acute toxicity was observed within 14 days, after administration with FBD extracts at the maximal tolerable dose of 69g/kg. These results suggested that FBD might be a potential and safe herbal agent for Alzheimer’s disease, and its nootropic action was mediated, in part, via enhancing the cholinergic nervous system.
  Zhihong Lin , Danni Zhu , Yongqing Yan and Boyang Yu
  FBD, a Chinese herbal formula, composed of Fu Ling [the sclerotium of the fungus of Poria cocos (Schw.) Wolf (Polyporaceae)], Bai Zhu [the rhizome of Atractylodes macrocephala Koidz.(Compositae)], and Danggui [the root of Angelica sinensis (Oliv.) Diels (Umbelliferae)], has been found beneficial in treating brain ischemia-reperfusion (I/R). In this work, oral pretreatment with supercritical CO2 extract (FBD-CO2, 37. 5 mg/kg) twice daily for 3.5 days, significantly attenuated brain infarction (p < 0.05), blocked neuron specific enolase (NSE) efflux (p < 0.05) in mice subjected to repetitive 10 min of common carotid artery occlusion following 24 h reperfusion, whether coupled with aqueous extract (FBD-H2O, 150 mg/kg) or not. Except atractylenolide I and pachymic acid, atractylenolide II, III, levistolid A, and ferulic acid isolated from FBD-CO2 alone protected neuron-like PC12 cells obviously and concentration-dependently against I/R-like insults (p < 0.05 ~ 0.01) induced by sodium dithionite (10 mM), monosodium glutamate (2 mM), KCl (0.2 M), or hydrogen peroxide (0.2 mM) at 1-100 μM. Even though at sub-active concentrations (< 1 μM), the combination of the six components contained in FBD-CO2 (10 μg/mL), protected markedly PC12 cells (p < 0.01), in a synergistic fashion. Moreover, intraperitoneal treatment with dual doses of 37. 5 mg/kg FBD-CO2 and 1. 2 mg/kg combination reduced both infarct size (p < 0.01 and p > 0.05, respectively) and NSE efflux (p < 0.05 and p > 0.05, respectively). Therefore, neuroprotection by FBD on I/R induced neuronal injury originated partially from the synergies of its compounds atractylenolide II, atractylenolide III, levistolid A and ferulic acid.
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