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Articles by Boukare Zeba
Total Records ( 5 ) for Boukare Zeba
  Boukare Zeba , Jacques Simpore and Odile Germaine Nacoulma
  β-lactamase production ways and inhibition patterns were investigated in cell suspensions of clinical isolates. The purpose of this research was prior to investigate the different β-lactamase molecular classes occurring in Burkina Faso owing to the local practice of β-lactam antibiotics. The use of specific inhibitors enabled to draw up an inhibition profile and consequently to assign an enzyme to accurate molecular class of β-lactamase. At the same time, β-lactamase expression ways were explored and correlated to the inhibition profiles. The current results pointed out two main groups of organisms. The first group of isolates secretes β-lactamases mainly by inducible way. Interestingly this bacterial group carries molecular class C of β-lactamase. The second group of isolates uses partial inducible and partial constitutive way for enzyme expression. These bacteria mostly carry molecular class A of β-lactamases. The sole exception encountered during these investigations is an organism, expressing exclusively by the constitutive way an enzyme that is found to belong to molecular class B of β-lactamases.
  Mindiediba Jean Bangou , Martin Kiendrebeogo , Moussa Compaore , Ahmed Yacouba Coulibaly , Nag-Tiero Roland Meda , Norma Almaraz Abarca , Boukare Zeba , Jeanne Millogo-Rasolodimby and Odile Germaine Nacoulma
  In the present study, 36 plant extracts, belonging to 6 families from Burkina Faso were used to evaluate their glutathione-S-transferase (GST), acetylcholinesterase (AChE), carboxylesterase (CES) and xanthine oxidase (XO) inhibitory activities and their phenolic, tannin and flavonoids contents by using spectrophotometrical methods. At 100 μg mL-1, Lippia chevalieri, Eclipta prostrata, Lantana camara and Indigofera pulchra extracts showed the best percentage of inhibition by regulating GST, AChE, CES and XO activities, respectively. The phytochemical investigations showed that all plant extracts were rich in biological compounds, namely phenolic, tannin and flavonoids. Particularly Cassia mimosoides extract presented the best phenolic, tannin and flavonoid contents. This result indicated that phenolic from Ceasalpiniaceae, flavonoids from Combretaceae and tannin from Verbenaceae contribute significantly to the inactivation of CES, AchE and GST, respectively. However, no significant correlation was found between polyphenolic compounds content and XO inhibitory activity. Present findings could partially justify the traditional uses of these plants in the treatment of mental disorders, gout, painful inflammations and cardiovascular diseases.
  Boukare Zeba , Martin Kiendrebeogo , Aline Lamien , Jean-Denis Docquier , Jacques Simpore and Odile Germaine Nacoulma
  Many clinical species of bacteria were isolated from biological samples such as urines, blood and wound in Saint Camille medical centre of Ouagadougou. Among the concerned species, the most important members were Escherichia coli and Klebsiella pneumoniae. These β-lactamases producing isolates were directly screened by PCR to identify the nature of the amplified genes responsible for penicillin destroying activity. Therefore specific TEM and SHV primers were used. The PCR products were sequenced. The sequencing results indicated that the parental forms blaTEM-1 and blaSHV-1 were the most common determinants of β-lactamase found, respectively in Escherichia species and Klebsiella pneumoniae. The bacterial susceptibility analysis by MICs measurement clearly correlated the presence of concerned β-lactamase determinants and their resistance patterns. This study is part of a set of investigations carried out by our laboratory to assess the β-lactamase incidence in the failure of β-lactam therapy. In particular, the purpose of this study was to determine the precise nature of β-lactamase supporting the low susceptibility of host bacteria towards penicillins.
  Leonard C. Bere , Jacques Simpore , Simplice D. Karou , Boukare Zeba , Augustin P. Bere , Elizabeth Bannerman , Jacques Bille and Mireille Dosso
  In Burkina Faso, a Western African country, reports on pneumococci carriage, resistance patterns and serotypes are inconsistent. The present study was conducted in order to evaluate these parameters. Thus 860 nasopharyngeal swabs were collected from children attending vaccination centers for pneumococci isolation, identification and serotype determination. The susceptibility to 16 antibiotics was assayed as recommended by the National Committee for Clinical Laboratory Standard (NCCLS). The results revealed that the majority of children were of 2 to 24 months age and 73.4% of children were well vaccinated. A carriage rate of 50.6% was recoded among the children. The main serotypes were: 6 (22.22%); 23 (16.67%); 7 and 9 (3.70%); 4, 11, 14, 15, 20 and 24 (1.85%). Serotypes19, 23, 6, 7 and 18 were linked to penicillin resistance. Globally, high resistance rates to: amikacin, tetracyclin, pefloxacin, cotrimoxazol and penicillins (resistance rates greater than 25%) were recorded; however the following antibiotics remained active on the strains: rifampicin, ceftriaxone, erythromycin, spectinomycin, chloramphenicol, vancomycin, lincomycin and ciprofloxacin.
  Mindiediba Jean Bangou , Martin Kiendrebeogo , Nag-Tiero Roland Meda , Ahmed Yacouba Coulibaly , Moussa Compaore , Boukare Zeba , Jeanne Millogo-Rasolodimby and Odile Germaine Nacoulma
  The aim of the present study was to evaluate some enzymes inhibitory effects of 11 plant species belonging to 9 families from Burkina Faso. Methanolic extracts were used for their Glutathione-s-transferase (GST), Acetylcholinesterase (AChE), Carboxylesterase (CES) and Xanthine Oxidase (XO) inhibitory activities at final concentration of 100 μg mL-1. The total phenolics, flavonoids and tannins were also determined spectrophotometrically using Folin-Ciocalteu, AlCl3 and ammonium citrate iron reagents, respectively. Among the 11 species tested, the best inhibitory percentages were found with Euphorbia hirta, Sclerocarya birrea and Scoparia dulcis (inhibition>40%) followed by Annona senegalensis, Annona squamosa, Polygala arenaria and Ceratotheca sesamoides (inhibition>25%). The best total phenolic and tannin contents were found with S. birrea with 56.10 mg GAE/100 mg extract and 47.75 mg TAE/100 mg extract, respectively. E hirta presented the higher total flavonoids (9.96 mg QE/100 mg extract). It's was found that Sclerocarya birrea has inhibited all enzymes at more than 30% and this activity is correlated to total tannins contents. Contrary to S. birrea, the enzymatic activities of E. hirta and S. dulcis are correlated to total flavonoids contents. Present findings suggest that the methanolic extracts of those plant species are potential inhibitors of GST, AChE, CES and XO and confirm their traditional uses in the treatment of mental disorders, gout, painful inflammations and cardiovascular diseases.
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