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Articles by Boniface N. Ejikeme
Total Records ( 2 ) for Boniface N. Ejikeme
  Emmanuel I. Ugwuja , Emmanuel I. Akubugwo and Boniface N. Ejikeme
  To determine the effect of hyperglycaemia on plasma copper and zinc in pregnancy complicated with diabetes mellitus, data for 40 diabetic and 40 non-diabetic pregnant women, matched for age, gestational age, Body Mass Index (BMI), parity and socioeconomic status from a cohort of 349 pregnant women recruited at gestational age of <25 weeks for the assessment of impacts of trace elements on pregnancy outcomes were analyzed. In addition to plasma copper and zinc which were determined by Atomic Absorption Spectrophotometer (Buck Scientific, Model AVG 210), plasma albumin, glucose, haemoglobin concentration and Total White Blood Cell Count (TWBC) were determined using standard laboratory methods. Although diabetic and non-diabetic pregnant women had comparable (p>0.05) age, gestational age, BMI and plasma copper, the former had significantly (p<0.05) lower plasma zinc (16.49±4.74 vs. 25.31±7.07 μmol/l) with significantly higher plasma glucose concentration (13.19±1.81 vs. 6.23±1.12 mmol/l). The diabetic subjects also had significantly (p<0.05) higher plasma albumin and TWBC when compared to their control counterparts (3.41±0.85 vs. 2.92±0.79 g/dl and 5.72±1.75 vs. 5.10±1.33 x 109/L respectively), although these were within the reference ranges. Correlation analysis showed that plasma glucose was negatively correlated with plasma zinc concentration (r = -0.239; p = 0.051). It is therefore concluded that hyperglycaemia in pregnancy complicated with diabetes mellitus impacts negatively on plasma zinc status, but lacks effect on plasma copper. This has important health implications for diabetic pregnant women and their newborns.
  Emmanuel I. Ugwuja , Boniface N. Ejikeme , Nicholas C. Ugwu , Ndudim C. Obeka , Emmanuel I. Akubugwo and Onyechi Obidoa
  With the increasing speculations of the involvement of nutrition, particularly trace elements in the pathogenesis of preeclampsia, a comparative study of plasma copper, iron and zinc levels was carried out between preeclamptic and non-eclamptic Nigerian women living in Abakaliki, Southeastern Nigeria. Data for 40 preeclamptic and 40 non-eclamptic women matched for age, gestational age, Body Mass Index (BMI), parity and socioeconomic status from a cohort of 349 pregnant women recruited at gestational age <25 weeks for the assessment of impacts of trace elements’ status on pregnancy outcomes were analyzed. In addition to trace elements which were determined by Atomic Absorption Spectrophotometer (Buck Scientific, Model AVG 210), Total White Blood Cell Count (TWBC) and Haemoglobin Concentration (HbC) were determined using standard laboratory techniques. The preeclamptic and the non-eclamptic women had comparable TWBC and HbC with the former having significantly (p < 0.05) higher blood pressure. However, although, the preeclamptic women had lower plasma copper, iron and zinc levels than the non-eclamptic women, only copper was found to be statistically significant (6.02±7.23 vs. 10.23±9.84 μmol/l, p<0.05). It is thus concluded that preeclampsia is associated with significant decrease in plasma copper. Further research is desired to elucidate the role of trace elements, especially copper in the pathogenesis of pregnancy induced hypertension.
 
 
 
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