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Articles by Bo Han
Total Records ( 2 ) for Bo Han
  Wenyan Wang , Minggen Cui and Bo Han
  In this paper, we present a new method for solving a class of singular two-point boundary value problems for certain ordinary differential equations having singular coefficients. The exact solution u(x) is represented in the form of series in the reproducing kernel space. In the mean time, the n-term approximate solution un(x) is obtained by solving a linear system of equations and is proved to converge to the exact solution. This method can avoid the Gram–Schmidt orthogonalization process, so as to improve the precision and decrease consumedly the runtime when the number of knots is the same, especially when the number of knots is large. It is efficiently applied to solve some model problems with the comparison between the numerical solutions and the exact solutions. The high precision of this method is demonstrated by the numerical examples.
  Zhuomin Wang , Bo Han , Zhuang Zhang , Jian Pan and Hui Xia
  Analysis of gene expression using RNA from the paraffin-embedded tissues is becoming an important way to study cancer pathogenesis. In this article, total RNA was extracted from tissue of 158 cases of paraffin-embedded tongue cancer, and expression of angiopoietin-like 4, tenascin-C and cathepsin-C were detected by real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Our results demonstrated that high expression level of angiopoietin-like 4 or tenascin-C was predictive of poor prognosis of tongue cancer patients (p=0.024 and p=0.011, respectively), especially when expression levels of both genes were concomitantly high (p=0.001). Additionally, high expression of angiopoietin-like 4 and tenascin-C, or concomitant high expression of angiopoietin-like 4 and tenascin-C were independent prognostic factors of poor survival in patients with tongue cancer. These results suggest that the improved method of RNA extraction is suitable for analysing gene expression of paraffin-embedded solid tumours. Angiopoietin-like 4 and tenascin-C, especially the combination of angiopoietin-like 4 and tenascin-C, are useful for predicting the prognosis of the patients with tongue cancer, independent of lymph node metastasis status.
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