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Articles by Bo Ding
Total Records ( 5 ) for Bo Ding
  Bo Ding and Li-juan Sun
  In this study, we propose an ontology-based framework to provide an integrated view, which could integrate various software resources and realize semantic interoperability between different software resources. Ontologies are divided into shared ontology and domain ontology. The design of shared ontology is described in detail. The shared ontology which has explicit ontological semantics, implements the uniform representation of heterogeneous information and helps to shield the heterogeneity of software resources systematically. The domain ontology is a domain-specific functional design ontology repository, in which, the invoking functions of the specific platform is encapsulated. The Collaborative Functional Design Environment (CFDE) is built through the shared ontology and the domain ontology. The CFDE facilitates the semantic interoperability among diverse software resources, which provides more software resources and better service to users.
  Bo Ding , Lin Mei and Xuejun Sha
  By discussing the development of 4-WFRFT, a discrete sequence algorithm for 4-WFRFT based on DFT is introduced and this makes it possible to use 4-WFRFT in a discrete time system. On the basis of analyzing the rotating, squeezing effect to the digital signal constellation by 4-WFRFT process also the similarity of 4-WFRFT signal to Gaussian distribution and the anti-scanning competence of 4-WFRFT signal, an alterable-parameter secure communication system is introduced based on 4-WFRFT secure communication system. Moreover, in the light of frequency-hopping patterns, a dynamic alterable-parameter strategy for single parameter 4-WFRFT and three strategies for multi-parameters 4-WFRFT are designed to avoid a non-receiver’s intercepting and decoding. "Tracking coefficient" is defined to judge the anti-scanning capacity. The results of simulation show that the alterable-parameter 4-WFRFT secure communication system has strong practical significance.
  Li-juan Sun and Bo Ding
  Because the different CAD systems use different concepts, attributes and relations to store data model, it is difficult to implement semantic interoperability among heterogeneous CAD systems. In this study, the Feature Command Ontology Model (FCOM) which is established, includes a number of Neutral Semantic Feature Commands (NSFCs) corresponding to the basic modeling operations of CAD systems. The FCOM which has explicit ontological semantics, provides the uniform representation of heterogeneous information and helps to shield the heterogeneity of data sources. Meanwhile, it is capable of dealing with modification and deletion operations besides common creation operations. Based on the FCOM, a synchronized collaborative design platform upon heterogeneous CAD systems is built; the real-time data exchange among heterogeneous CAD systems is achieved in a semantic way.
  Bo Ding , Xiao-Yang Yu and Li-Juan Sun
  The spring up of cloud computing gives product manufacturing a new solution and chance to realize resource sharing and cooperative work between enterprises for global manufacturing. A collaborative manufacturing resource sharing platform is built based on cloud services, which implements to effectively describe information, resources and knowledge during manufacturing process by abundant semantics. The cloud services are the combination of cloud computing and ontology technique. Cloud computing utilizes virtualization technology to encapsulate collaborative manufacturing resources as services to shield the distribution of collaborative manufacturing. The cloud service integration model is built based on ontology technique. The cloud service integration model implements the uniform representation of heterogeneous information and helps to shield the heterogeneity of manufacturing resources systematically. Finally, a case study of the whole design of a decelerator is presented to validate the feasibility and effectiveness of the approach.
  Bo Ding and Peter Lengyel
  The murine p200 family protein, p204, modulates cell proliferation and tissue differentiation. Many of its activities are exerted in the nucleus. However, in cardiac myocytes, p204 accumulated in the cytoplasm. A yeast two-hybrid assay revealed a p204-cytoplasmic Ras protein interaction. This was confirmed (i) by coimmunoprecipitation of p204 with Ras in mouse heart extract and with endogenous or ectopic H-Ras and K-Ras in cell lysates as well as (ii) by binding of purified H-Ras-GTP to purified p204 in vitro. p204 inhibited (i) the cleavage of RasGTP to RasGDP by RasGAP; (ii) the binding to RasGTP of Raf-1, phosphatidylinositol 3-kinase, and Ral-GDS, effectors of Ras signaling; and (iii) activation by the Ras pathway of the phosphorylation and thus activation of downstream targets (e.g. MEK, Akt, and p38MAPK). Oncogenic Ras expression triggered the phosphorylation and translocation of p204 from the nucleus to the cytoplasm. This is expected to increase the interaction between the two proteins. Translocation triggered by Ras oncoprotein was blocked by the LY294002 inhibitor of phosphatidylinositol 3-kinase. Ras did not promote phosphorylation or translocation to the cytoplasm of mutated p204 in which serine 179 was replaced by alanine. p204 overexpression inhibited the anchorage-independent proliferation of cells expressing RasQ61L oncoprotein. Ras oncoprotein triggered in MEF3T3 cells the rearrangement of the actin cytoskeleton and the enhancement of cell migration through a membrane. Overexpression of p204 inhibited both. Ras oncoprotein or activated, wild-type Ras was described to increase Egr-1 transcription factor expression. We report that a sequence in the gene encoding p204 bound Egr-1, and Egr-1 activated p204 expression. Ras oncoprotein or activated wild-type Ras increased the expression in 3T3 cells of p204 together with that of Egr-1. Furthermore, the activation of expression of a single copy of K-ras oncogene in cultured murine embryonic cells induced the expression of a high level of p204 as well as its distribution between the nuclei and the cytoplasm. Thus, p204 may serve as a negative feedback inhibitor of Ras activity.
 
 
 
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