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Articles by Bing Li
Total Records ( 6 ) for Bing Li
  Bing Li , Bingjie Sun , Xuan Wang , Xintong Huang and Xiaoyu Xiu
  Due to the advance of many social network applications, social group feature analytics are attracting a lot of attention. In the meantime, microblogging, as a kind of social network application, attracts more and more people to use it. With the utilization of bigger and broader crowds over microblogging, surveying massive user features will be an important aspect of exploitation of crowd-sourced data. For better understanding microblogging user group features, in this study, a user classification approach was proposed by means of Boolean operations and it is easily find different microblogging user group features by this approach. In the experiment, some facts were discussed on the exploratory survey to exploit a great deal of microblogging data and how to analyze the features of the different user groups.
  Jianyong Li , Yuanguang Yu , Yajun Yang , Xiwang Liu , Jiyu Zhang , Bing Li , Xuzheng Zhou , Jianrong Niu and Xiaojuan Wei
  Antioxidant activity of Aspirin Eugenol Ester (AEE) for aging model of mice by D-galactose for 8 weeks was investigated. MDA and lipofuscin contents of mice serum and heart, liver were selected as indexes to reflect antioxidant activity. The results showed that the small doses of AEE can effectively remove free radicals caused by D-galactose and large doses of AEE can make free radicals level below the normal level. There were some relationships between dose and effect. Compared with precursor drug aspirin and eugenol, AEE also has stronger antioxidant activity.
  Ji-Yu Zhang , Xu-Zheng Zhou , Bing Li , Ya-Jun Yang , Xiao-Juan Wei , Jian-Rong Niu , Jian-Yong Li , Jin-Shan Li and Xi-Wang Liu
  The purpose of this study was to evaluate the treatment efficacy of 1% doramectin injection against nematode in swine infected naturally in China and determine dosage regimen of doramectin in swine. A controlled clinical study was conducted on 200 swine infected with nematode naturally in Lanzhou. The tested groups included doramectin 400, 300 and 150 μg kg-1 by IM, ivermectin 300 μg kg-1 by SC as drug control group and blank control group. The results showed the efficacy against nematode of high dosage doramectin (400 μg kg-1) was significantly difference from middle and low dosage group (p<0.05) and was significantly difference from control ivermectin group (p<0.01). The persistent period of nematocidal with high, middle and low dosage were 28, 28 and 21 days, respectively. The body weight gain of high, middle dosage doramectin and ivermectin group were significantly difference from the low dosage doramectin and untreated control (p<0.05 and p<0.01). So, the recommended dosage regimen of doramectin against swine’s nematode was 300 μg kg-1 body weights by IM for once administration of medicine.
  Rui-Ai Chen , Bing Li , Xianhao Zhang , Haopeng Liu and Dongsheng He
  Seventy four pathogenic swine Escherichia coli strains were isolated from large-scale pig farms in 5 provinces in Southern China. Fourty seven kinds of single-factor O-antigen serum were used to classify the serotypes of isolates. The serotypes of 66 of 74 swine Escherichia coli strains had been identified which belonged to 14 serotypes. O107, O101, O9, O26 and O60 were the dominant serotypes. There were 8 strains failed to be identified, accounting for 10.8% of the total strains. Eighteen swine Escherichia coli strains were selected from the dominant serotypes to pathogenicity test in mice. The results showed that 7 of 18 representative strains were virulent strains. Further, researchers analyzed the Outer Membrane Protein (OMP) of 7 virulent strains, the result showed that OMP of 7 strains, respectively from 1-3 protein bands which belonged to 3 OMP type (I~III). This is first time in Southern China to investigate systematically on the predominant serotypes of pathogenic swine Escherichia coli and laid a foundation on the prevention and control of porcine colibacillosis as well as the research of new OMP subunit vaccine.
  Zhaopeng Chu , Bing Li , Hai Xiao and Lan Lu
  With the background of innovation-driven economic growth, how to establish the effective indigenous technological innovation process is the most important issue to improve national technological innovative ability. In order to explore the paths and mechanisms of technological innovation, this study conducts such an empirical study on the process of indigenous technological innovation in Shenzhen City of China based on co-integration test, error correction model and Granger causality test. The empirical results show that there exists the long-term stability of the dynamic equilibrium among expenditures on R&D, number of patents applications granted and value of intellectual property rights of high-tech products. The anti-driving mechanism reverses feedback from the terminal of technological innovation activities to the upstream of R&D investments and patents output. It is very important for improving the efficiency of indigenous technological innovation process to strengthen R&D process management, perfect the innovation cooperation mechanism and speed up the transformation of independent intellectual property rights achievements.
  Midori Umekawa , Wei Huang , Bing Li , Kiyotaka Fujita , Hisashi Ashida , Lai-Xi Wang and Kenji Yamamoto
  Endo-β-N-acetylglucosaminidase from Mucor hiemalis (Endo-M), a family 85 glycoside hydrolase, acts on the β1,4 linkage of N,N`-diacetylchitobiose moiety in the N-linked glycans of glycoproteins and catalyzes not only the hydrolysis reaction but also the transglycosylation reaction that transfers the releasing sugar chain to an acceptor other than water to form a new glycosidic linkage. The transglycosylation activity of Endo-M holds a great promise for the chemo-enzymatic synthesis and glyco-engineering of glycoproteins, but the inherent hydrolytic activity for product hydrolysis and low transglycosylation have hampered its broad applications. This paper describes the site-directed mutagenesis on residues in the putative catalytic region of Endo-M to generate mutants with superior transglycosylation activity. Two interesting mutants were discovered. The Y217F mutant was found to possess much enhanced transglycosylation activity and yet much diminished hydrolytic activity in comparison with the wild-type Endo-M. Kinetic analyses revealed that the Km value of Y217F for an acceptor substrate 4-methylumbelliferyl-β-L-N-acetylglucosaminide was only one-tenth of that of the wild-type, implicating a much higher affinity of Y217F for the acceptor substrate than the wild-type. The other mutant, N175A, acts like a glycosynthase. It was found that mutation at Asn175"knocked out" the hydrolytic activity, but the mutant was able to take the highly active sugar oxazolines (the transition state mimics) as donor substrates for transglycosylation. This is the first glycosynthase derived from endo-β-N-acetylglucosaminidases that proceed via a substrate-assisted mechanism. Our findings provide further insights on the substrate-assisted mechanism of GH85. The usefulness of the novel glycosynthase was exemplified by the efficient synthesis of a human immunodeficiency virus, type 1 (HIV-1) glycopeptide with potent anti-HIV activity.
 
 
 
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