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Articles by Bin Zhao
Total Records ( 4 ) for Bin Zhao
  Lianjun Liu , Bin Liu , Lihui Dong , Jie Zhu , Haiqin Wan , Keqin Sun , Bin Zhao , Haiyang Zhu , Lin Dong and Yi Chen
  In situ FT-IR was employed to investigate CO or/and NO interaction with CuO supported on Ce0.67Zr0.33O2 (hereafter denoted as CZ) catalysts. The physicochemical properties of CuO–CZ were also studied by combination of XRD, TPR and NO + CO activity tests. The results indicated that the dispersed CuO species were the main active components for this reaction. The catalysts showed different activities and selectivities at low and high temperatures, which should be resulted from the reduction of dispersed copper oxide species. This reaction went through different mechanisms at low and high temperatures due to the change of active species. FT-IR results suggested: (1) CO was activated by oxygen originating from CZ support, which led to surface carbonates formation, and partial dispersed CuO was reduced to Cu+ species above 150 °C; (2) NO interacted with the dispersed CuO and formed several types of nitrite/nitrate species, whereas crystalline CuO made little contribution to the formation of new NO adsorbates; (3) NO was preferentially adsorbed on CuO–CZ catalysts compared with CO in the reactants mixture. These adsorbed nitrite/nitrate species exhibited different thermal stability and reacted with CO at 250 °C. As a result, a possible mechanism was tentatively proposed to approach NO reduction by CO over CuO–CZ catalyst.
  Lirong Lei , Yan Wu , Shengqiang Lu , Bin Zhao and Yishu Liu
  Background and Objective: Depression is a psychiatric disorder and inflammation facilitates the depression. Complexity of symptoms related to depression among different individuals and different therapeutic responses exhibited by the use of available antidepressants show that a need to identify novel antidepressants is there. Thus present study evaluates the effect of Triptolide (TPL) on depressive like behavior induced by lipopolysaccharide (LPS) in mice. Materials and Methods: All the mice were challenged with LPS (0.83 mg kg–1, i.p.) 30 min after the administration of 5 mg kg–1 of TPL. Several behavioral parameters were studied including open field test, forced swim test, tail suspension test and sucrose preference test. The level of pro-inflammatory cytokines and oxidative stress parameters were estimated in the brain tissues of LPS challenged mice. Moreover, level of brain derived neurotrophic factor (BDNF) in the brain tissues and plasma concentration of corticosteroid was estimated in LPS challenged mice. Results: Data given in the study suggested that treatment with TPL attenuates the behavioral parameters affected by LPS in mice. Level of pro-inflammatory cytokines and oxidative stress parameters were significantly decreases in the prefrontal cortex and hippocampus of TPL treated group compared to negative control group. Plasma concentration of corticosteroid significantly decreases and level of BDNF in brain tissue significantly increases in TPL treated group than negative control group of mice. Conclusion: Present study concludes that treatment with TPL attenuates the depressive behavior by decreasing the level of cytokines and oxidative stress parameter in the brain tissues of LPS challenged mice.
  Qun-Ying Lei , Heng Zhang , Bin Zhao , Zheng-Yu Zha , Feng Bai , Xin-Hai Pei , Shimin Zhao , Yue Xiong and Kun-Liang Guan
  TAZ is a WW domain containing a transcription coactivator that modulates mesenchymal differentiation and development of multiple organs. In this study, we show that TAZ is phosphorylated by the Lats tumor suppressor kinase, a key component of the Hippo pathway, whose alterations result in organ and tissue hypertrophy in Drosophila and contribute to tumorigenesis in humans. Lats phosphorylates TAZ on several serine residues in the conserved HXRXXS motif and creates 14-3-3 binding sites, leading to cytoplasmic retention and functional inactivation of TAZ. Ectopic expression of TAZ stimulates cell proliferation, reduces cell contact inhibition, and promotes epithelial-mesenchymal transition (EMT). Elimination of the Lats phosphorylation sites results in a constitutively active TAZ, enhancing the activity of TAZ in promoting cell proliferation and EMT. Our results elucidate a molecular mechanism for TAZ regulation and indicate a potential function of TAZ as an important target of the Hippo pathway in regulating cell proliferation tumorigenesis.
  Bin Zhao , Xin Lin , Li Lei , David C. Lamb , Steven L. Kelly , Michael R. Waterman and David E. Cane
  Cytochrome P450 170A1 (CYP170A1) is encoded by the sco5223 gene of the Gram-positive, soil-dwelling bacterium Streptomyces coelicolor A3(2) as part of a two-gene cluster with the sco5222 gene. The SCO5222 protein is a sesquiterpene synthase that catalyzes the cyclization of farnesyl diphosphate to the novel tricyclic hydrocarbon, epi-isozizaene (Lin, X., Hopson, R., and Cane, D. E. (2006) J. Am. Chem. Soc. 128, 6022–6023). The presence of CYP170A1 (sco5223) suggested that epiisozizaene might be further oxidized by the transcriptionally coupled P450. We have now established that purified CYP170A1 carries out two sequential allylic oxidations to convert epi-isozizaene to an epimeric mixture of albaflavenols and thence to the sesquiterpene antibiotic albaflavenone. Gas chromatography/mass spectrometry analysis of S. coelicolor culture extracts established the presence of albaflavenone in the wild-type strain, along with its precursors epi-isozizaene and the albaflavenols. Disruption of the CYP170A1 gene abolished biosynthesis of both albaflavenone and the albaflavenols, but not epi-isozizaene. The combined results establish for the first time the presence of albaflavenone in S. coelicolor and clearly demonstrate that the biosynthesis of this antibiotic involves the coupled action of epi-isozizaene synthase and CYP170A1.
 
 
 
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