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Articles by Bin Guo
Total Records ( 5 ) for Bin Guo
  Meixia Ye , Lexiang Ji , Zhong Chen , Hao Li , Bin Guo , Jia Wang , Weihua Liao and Xinmin An
  A number of programs have been developed with Perl for automatically integrating biological data, especially with BioPerl. Many BioPerl modules have enabled access to classic bioinformatics, including accessing gene sequence, transforming formats of database, manipulating sequences and searching for similar sequence. However, there are few available tools that can be used to automatically download batches of upstream sequence. Here, we report a method combining results of querying biomaRt with ARUPSEQ program, which can be used to solve this problem. The main steps for users include firstly, downloading genome sequences for target species, secondly, querying biomaRt to get a gene information list, thirdly, inputting a desired length and selecting an option for different start point. ARUPSEQ will be a strategy for improving efficiency on accessing upstream sequence.
  Haichang Gao , Boqin Feng , Yun Hou , Bin Guo and Li Zhu
  A hybrid adaptive SAGA based on mutative scale chaos optimization strategy (CASAGA) is proposed to solve the slow convergence, incident getting into local optimum characteristics of the Standard Genetic Algorithm (SGA). The algorithm combined the parallel searching structure of Genetic Algorithm (GA) with the probabilistic jumping property of Simulated Annealing (SA), also used adaptive crossover and mutation operators. The mutative scale Chaos optimization strategy was used to accelerate the optimum seeking. Compared with SGA and MSCGA on some complex function optimization and several TSP combination optimization problems, the CASAGA improved the global convergence ability and enhanced the capability of breaking away from local optimal solution.
  Yang Liu , Guanyu Che , Yixue Sun , Bo Jin , Bin Guo and Xueming Zhang
  Previously researchers reported that Etv4, one of the members of Ets transcription factor Etv5 subfamily, remained at a low level during the normal sexual maturity in testis but a high level in epididymis. Since, the development of spermatogonia and the expression of the regulatory molecules during spermatogenesis could be altered in detrimental environment. In order to examine whether the expression of Etv4 were changed in male reproductive system when cryptorchidism occurred, expressions of Etv4 in testis and epididymis were examined in artificial Unilateral Cryptorchidism Mouse Model. Samples were collected on the 3rd, 6th, 12th and 18th days after cryptorchidism surgery, respectively. The effect of cryptorchidism was confirmed histologically. In cryptorchidism testis, Etv4 mRNA remained steadily at all time points compared with that in the contralateral (p>0.05). However, it decreased significantly in cryptorchidism epididymis compared with its contrapart on the same time point (p<0.01) and its decrease continued along with the time especially on day 12 (p<0.05) and day 18 (p<0.01) compared with day 3 in surgery-lateral epididymis. Collectively, Etv4 might play an essential role for sperm maturation in epididymis.
  Guanyu Che , Yang Liu , Yixue Sun , Bin Guo and Xueming Zhang
  The importance of ETS transcription factor Etv5 on the self-renewal of Spermatogonial Stem Cells (SSCs) has been well documented recently. Previously, the researchers reported that its peer Etv4 remained at a low level during the normal sexual maturity in mouse. It’s well known that the development of spermatogonia and the expression of the regulatory molecules could be changed during the regeneration after damage of the seminiferous epithelia. To test whether the expression of Etv4 was also altered in male reproductiove system after damage, expressions of Etv4 in testis and epididymis were examined in Busulfan-Treated Mouse Model. Mouse testis and epididymis were collected on the 0th, 3rd, 5th, 8th, 10th and 18th days after busulfan injection, respectively. The effect of busulfan treatment was confirmed histologically. In testis, Etv4 mRNA declined evidently on day 5 and 8 and decreased significantly on day 10 (p<0.05) while it remained a relatively higher level at all time points in epididymis and decreased significantly on day 8 (p<0.05). Collectively, Etv4 might be involved in the regeneration of seminiferous epithelia and the maturation of sperm in epididymis.
  Xiangwei Huang , Xia Li and Bin Guo
  KLF6 (Kruppel-like factor 6) is a zinc finger transcription factor and a tumor suppressor that is frequently mutated in prostate cancer. KLF6 suppresses tumor growth and induces apoptosis in cancer cells through mechanisms still not defined. Here we show that KLF6 induces apoptosis in prostate cancer cells by ATF3 (activating transcription factor 3) expression. KLF6 binds directly to and activates the ATF3 promoter. ATF3 induced apoptosis when ectopically expressed in cells, whereas knockdown of ATF3 by small interference RNA blocked KLF6-induced apoptosis. KLF6 mutants derived from clinical prostate cancers failed to activate the ATF3 promoter and were unable to induce apoptosis. Furthermore, stress conditions (exposure to staurosporine and hypoxia induced by sodium azide) caused significant increase in ATF3 expression and induced apoptosis, whereas knockdown of KLF6 by small interference RNA blocked the increase of ATF3 as well as the induction of apoptosis in these conditions. Thus, ATF3 is a key mediator of KLF6-induced apoptosis in prostate cancer cells.
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