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Articles by Basaran KARADEMIR
Total Records ( 3 ) for Basaran KARADEMIR
  Basaran Karademir , Guler Karademir , Serdal Tarhane , Unal Ciftci , Evren Koc , Yusuf Ersan and Kadir Bozukluhan
  This study was carried out to determine the changes of Cu, Zn, Fe, Ca, Mg, K and Na levels in liver during treatment of oral ampicillin in mice. The investigation was supported by serum ALT and AST enzyme activities, serum Total Protein (TP), Albumin (ALB), Globulin (GLB) levels determinations. Twenty one male Swiss albino mice (weighing 28.36±2.33 g, aged 4 months) were used for this study. The standard commercial diet was given to all groups. First group (A) were used control and took only tap water. Other groups were received water with ampicillin. Dose of ampicillin for second (B) and third (C) groups were as follows; 8 and 40 mg/100 mL in drinking water. Dry ashing method and Flame Atomic Absorption Spectrometer (FAAS) were used for determination of minerals. Statistically significant increase (minimum p<0.05) for Cu, Ca and Na and decrease for K were observed. Significant positive correlation between Cu-Ca, Cu-Na, Zn-Mg, Ca-Na, Mg-K (minimum r = 0.450, p<0.05) and negative correlation between Cu-K (r = 0.456, p<0.05) were observed. There was a significant difference in AST levels of groups (p<0.001) but not other serum parameters of ALT, TP, ALB and GLB. These results indicate that oral ampicillin treatment affect liver Cu, Ca, Na and K levels. Therefore, this fluctuation must be considered on ampicillin applications during antimicrobial therapy.
  Basaran Karademir , Huseyin Eseceli and Asim Kart
  This study was carried out to determine the effect of oral levothyroxine sodium (T4) application on some serum mineral (Zn, Fe, Ca and Mg) concentrations during CuSO4 toxication (1%). Forty male New Zealand rabbits (6 months-old, weighing 2.16±0.08 kg) were allocated to 4 groups. All groups received 1% CuSO4 (*5H2O) (Copper (II) sulfate pentahydrate M102787) in drinking water. Except for control group (group A), T4 was orally applied to 3 experimental groups at doses of 1.67 (group B), 3.33 (group C) and 6.67 μg kg-1 per bw per day (group D) for 2 days. Serum Cu measurements were performed by Atomic Absorption Spectrometer equipped with Flame system. Serum Zn levels in groups C and D were higher than in group A, while serum Ca levels in groups C and D were found to be lower than in group A (p<0.05), on the last day. There were significant differences for all mineral levels with respect to time (p<0.001). There was also a significant interaction between the dose of T4 applied (groups A-D) and time (p<0.01), except for Fe levels (p>0.05). However, there were significant differences only in Zn and Ca levels in multiple comparisons (p<0.05). A significant correlation was also found between T4 and Zn (r: -0.537, p<0.001) as well as T4 and Ca (r:-0.593, p<0.001) levels. In addition, administration of T4 along with 1% CuSO4 affected serum Zn, Ca and Mg levels significantly (p<0.05). At the result, T4 administration at different doses with 1% CuSO4 caused an increase in serum Zn but a decrease in serum Ca levels. However, the administration of this combination showed no significant effect on serum Fe and Mg levels.
  Yusuf ERSAN , Evren KOC , Ismail ARI and Basaran KARADEMIR
  Fluoride intake in high doses has toxic effects on various organs. Chronic fluorosis results in tubular degenerations, inflammation, fibrosis, parenchymatous nephritis, cloudy swellings, and dilations of convoluted tubules. In addition to these effects, fluoride causes deteriorative effects on the skeleton, teeth, and soft tissues. The goal of this study was to examine the impacts of chronic fluorosis on the liver tissues of mice. Materials and methods: One control group and 3 experimental groups, each group consisting of 4 male and 4 female mice, were formed to conduct the experiment. A stock solution including 2000 ppm fluoride was prepared by solving 4.44 g of NaF in 1 L of distilled water. Water with 10, 20, and 40 ppm fluoride was obtained by diluting the stock solution to give to the animals. Animals in the control group had free access to tap water with 0.3 ppm fluoride. Animals in experimental group 1 were orally given distilled water with 10 ppm fluoride, water with 20 ppm fluoride was orally given to the animals in experimental group 2, and the animals in experimental group 3 were orally given distilled water containing 40 ppm fluoride for 90 days. The animals were killed under light ether anesthesia to obtain specimens from the livers. Slides were prepared under the light microscope to examine histopathological anomalies and then photographs were taken. Results: Histopathological disorders were observed on the slides prepared from the liver specimens of the animals exposed to chronic fluorosis depending on doses of chemicals given to the animals. Hyperemia, local necrosis, hydropic degeneration, vacuolar degenerations, and swelling on hepatocytes around the central vein were detected. Conclusion: Depending on the doses of fluoride applied to the animals, degenerations in the tissues around the central vein increase.
 
 
 
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