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Articles by Balasubramanian Rajkapoor
Total Records ( 5 ) for Balasubramanian Rajkapoor
  Ramachandran Venugopal , Palaniyandi Senthilnathan , Venkatraman Magesh , Balasubramanian Rajkapoor and Dhanapal Sakthisekaran
  The present study was conducted to ascertain the chemotherapeutic efficacy of Solanum trilobatum when administered along with paclitaxel against experimental lung carcinogenesis. Healthy male Swiss albino mice (6-8 weeks old) were treated with Benzo (a) pyrene (50 mg kg-1 body weight) to induce lung cancer. Paclitaxel at a dose of 33 mg kg-1 body weight intraperitoneally and Solanum trilobatum 200 mg kg-1 body weight orally was administrated for four weeks to lung cancer bearing animals. The level of lipid peroxides (LPO) was found to be markedly increased in carcinogen-administered animals, in contrast the activities/levels of the antioxidant status both in lung and liver were decreased in carcinogen administered animals. Upon Solanum trilobatum along with Paclitaxel administration the above pathological changes were bring back to near normal. From these findings we have concluded that Solanum trilobatum when administered along with paclitaxel prevents LPO and protects antioxidant system strongly aganist Benzo(a)pyrene induced lung cancer.
  Raju Senthil Kumar , Balasundaram Jayakar and Balasubramanian Rajkapoor
  The antitumour activity of ethanol extract of Indigofera trita L.f (EIT) was evaluated against Ehrlich Ascites Carcinoma (EAC) tumour model in Swiss albino mice on dose dependent manner. The activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumour volume. Oral administration of EIT (200 and 400 mg kg-1) increased the survival time and decreased the average body weight of the tumour bearing mice. After 14 days of inoculation, EIT was able to reverse the changes in the hematological parameters, protein and PCV consequent to tumour inoculation. Oral administration of EIT was effective in reducing solid tumour mass development induced by EAC cells. The results indicate that EIT possess significant antitumour activity on dose dependent manner.
  Ramachandran Venugopal , Dhanapal Sakthisekaran , Balasubramanian Rajkapoor and Ikuo Nishigaki
  The aim of the present study was to evaluate the protective effect of mangiferin on Human Umbilical Vein Endothelial Cells (HUVEC) against glycated protein-iron chelate induced toxicity. HUVEC incubated in glycated protein either alone or combined with iron chelate showed a significant (p< 0.001) elevation of Lipid Peroxidation (LPO) accompanied by depletion of Superoxide Dismutase (SOD), catalase, Glutathione Peroxidase (GPx) and Glutathione Reductase (GR), in addition to increased microsomal cytochrome c reductase and decreased glutathione S-Transferase (GST). Treatment of HUVEC with mangiferin at a concentration of 5 and 10 μg significantly decreased the level of LPO and altered antioxidants, cytochrome c reductase and GST levels to near normal in a dose dependent manner. Present results suggest that mangiferin have protective effect against glycated protein-iron chelate induced toxicity.
  Raju Senthil Kumar , Rangasamy Manivannan , Ayyasamy Balasubramaniam and Balasubramanian Rajkapoor
  The ethanol extract of Indigofera trita (EIT) was studied for its antioxidant and hepatoprotective properties. The ethanol extract exhibited potent in vitro antioxidant activity as evidenced by the low IC50 values in the scavenging of ABTS, DPPH and hydroxyl radical methods. The IC50 values obtained were 9.50 ± 0.50 and 19.91 ± 1.73 μg mL-1, respectively for ABTS and DPPH methods. The IC50 values obtained for hydroxyl radical scavenging by p-NDA and deoxyribose methods were found to be 104.50 ± 4.50 and 99.00 ± 0.28 μg mL-1, respectively. The treatment with the EIT at 200 and 400 mg kg-1 body weight showed a significant and dose dependent decrease in the levels of SGOT, SGPT, ALP and TBARS and significant increase in the levels of albumin, total protein, SOD and catalase, when compared to CCl4 treated rats. The treatment with EIT exhibited better results than the standard vitamin-E treatment in some of these parameters. Thus, the EIT showed significant antioxidant and hepatoprotective activity. These results were also confirmed by the histological observation.
  Ikuo Nishigaki , Balasubramanian Rajkapoor , Peramaiyan Rajendran , Ramachandran Venugopal , Ganapathy Ekambaram , Dhanapal Sakthisekaran and Yutaka Nishigaki
  Consumption of fruits and vegetables has been associated with a low incidence of cardiovascular and other chronic diseases. The present study was aimed at evaluating the protective effects of fresh apple extract (AE) on human umbilical vein endothelial cells (HUVEC) exposed to cytotoxic glycated protein (GFBS)/iron (FeCl3) chelate. The experimental design comprised 10 groups with 5 flasks in each group. Group I was treated with 15% foetal bovine serum (FBS). Groups II, III and IV were treated with GFBS (70 µM), FBS + FeCl3 (20 µM), and GFBS + FeCl3, respectively. The other six groups were as follows: Group V, GFBS + AE (100 µg); Group VI, FBS + FeCl3 + AE (100 µg); Group VII, GFBS + FeCl3 + AE (100 µg); Group VIII, GFBS + AE (250 µg); Group IX, FBS + FeCl3 + AE (250 µg); and Group X, GFBS + FeCl3 + AE (250 µg). After 24 h incubation, cells were collected from all the experimental groups and assessed for lipid peroxidation (LPO) and activities of the antioxidant enzymes cytochrome c reductase and glutathione S-transferase (GST). HUVEC incubated with glycated protein (GFBS) either alone or combined with iron chelate showed a significant (p < 0.001) elevation of LPO accompanied by depletion of superoxide dismutase, catalase, glutathione peroxidase (GPx) and glutathione reductase (GR), in addition to increased microsomal cytochrome c reductase and decreased GST activities. Treatment of GFBS- or GFBS + FeCl3-exposed HUVEC with AE at 100 or 250 µg significantly decreased the level of LPO and returned the levels of antioxidants cytochrome c reductase and GST to near normal in a dose-dependent manner. The extracts recovered viability of HUVEC damaged by GFBS-iron treatment in a concentration-dependent manner. These findings suggest a protective effect of AE on HUVEC against glycated protein/iron chelate-induced toxicity, which suggests that AE could exert a beneficial effect by preventing diabetic angiopathies.
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