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by
Bagher Larijani |
Total Records (
5 ) for
Bagher Larijani |
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Shirin Hasani Ranjbar
,
Bagher Larijani
and
Mohammad Abdollahi
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Improving the world health has resulted in increasing some kind of debilitating diseases. Among these debilitating diseases, the type 2 diabetes is one of the major concerns. In the recent years, new treatment options such as herbal products have emerged to improve glycemic control in these patients. However, the efficacy and safety of these new remedies are still a concern. Recent updates prove benefit of some herbal medicines like Citrullus Colocynthis, Silybum marianum, Plantago ovata, Teucrium polium, Vaccinium myrtillus, Urtica dioica, Medicago sativa, Punica granatum, Panax ginseng, Aloe vera, Allium sativum, Satureja khuzestanica and Trigonella foenum-graecum. Although, animal studies seem complete in demonstrating benefit of these medicines but clinical trials are not complete yet. Standardization of genus and type of the plant, higher sample size trials to specify the dosage and time treatment, or synergistic effects when used in mixtures with other herbs/drugs and profiling adverse effects/toxicities are the issues that should be taken into account in future. The constituents of these medicinal herbs should be targeted for new anti-diabetic drugs. |
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Shirin Hasani-Ranjbar
,
Somayeh Khosravi
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Neda Nayebi
,
Bagher Larijani
and
Mohammad Abdollahi
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This review focuses on the efficacy and safety of medicinal plants which have been utilized in traditional medicine for anti-aging purpose. All relevant databases were searched for the terms “anti-aging” and “herbs” or “medicinal plant” without limitation up to 30th January 2011. All the clinical and non-clinical studies with the outcome of change in aging process were included. Search in databases resulted in 1733 articles that on the basis of inclusion/exclusion criteria, 67 studies were finally included. Six human and 61 animal studies were reviewed for the effect of anti-aging herbs on aging process. Most of the studies showed significant improvement in brain function (memory, cognitive, anxiety), sexual disorder and skin wrinkle. From the performed studies, the exact mechanism of anti-aging action and side effect cannot be concluded and thus further studies would be helpful. |
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Bagher Larijani
,
Sima Hashemipour
,
Reza Baradar-Jalili
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Mohammad Reza Mohajeri
and
Seyed Ahmad Sajjadi
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This study was designed to investigate the effects of sandostatin LAR after multiple injections and duration of its effect on acromegal patients. Five acromegal patients were treated with sandostatin LAR. After performing Octreotide test, 30 mg sandostatin LAR was administered for 3 times and the frequency of mean daily Growth Hormone (GH) less than 5μg L-1 were compared between 1st and 3rd injections. Then drug’s acting period was assessed (G.H <5 μg L-1). In addition in 3 patients the efficacy of 30 and 40 mg daily dosages were compared with each other. No significant relationship was found between the response rate to sandostatin and short acting Octreotide. Also the frequency of GH <5 μg L-1 after 3rd injection was more than scale after the first injection (p<0.01). The drug’s effect continued for at least 42 days after injections. Octreotide test (with single dose injection) wasn’t proved to be a reliable method for prediction of patients` response to treatment. Measuring GH after multiple injections is a better method for this purpose and it`s also better to determine injection intervals in each patient individually. |
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Shirin Hasani-Ranjbar
,
Neda Nayebi
,
Bagher Larijani
and
Mohammad Abdollahi
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This review focuses on the efficacy and safety of Teucrium species that are effective in the management of different conditions in human and animal. Embase, Scopus, Pubmed, Google Scholar and IranMedex databases were searched up to 11th May 2009. The search terms were Teucrium or germander or Calpoureh. All of the human and animal studies considered the effects of Teucrium with the key outcome of change in blood glucose, serum lipids, anti-oxidant parameters, hepatic enzymes, anti-inflammation, analgesic effects, anti-ulcer effects anti-microbial effect and toxic effects were included. Studies performed on cell lines, in vitro studies, reviews and letters to editors were excluded. Of initial search, 7325 record were reviewed for inclusion or exclusion in study. Finally, 68 studies were included. Some animal and one human study showed hypoglycemic effects of Teucrium. In one animal study, Teucrium decreased serum cholesterol and triglyceride in hyper-lipidemic rats. Some studies indicated anti-oxidant, anti-spasmodic, anti-nociceptive and anti-inflammatory properties of Teucrium. According to histopathological and biochemical evidences, high doses or long-term administration of Teucrium may induce progressive impairment of neuromuscular coordination and reversible or irreversible hepatic damage. Teucrium has antidiabetic effect by enhancing secretion of insulin from the pancreas. The flavonoids and sterols are responsible for the anti-inflammatory activity of this plant. Isolation and characterization of Teucrium constituents is suggested to reach suitable drugs. |
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Avin Mehri
,
Shirin Hasani-Ranjbar
,
Bagher Larijani
and
Mohammad Abdollahi
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This review focuses on the efficacy and safety of Urtica dioica which has been utilized in traditional medicine for management of diabetes. All relevant databases including Pubmed, Google Scholar, Web of Science, Scopus, Iranmedex and MD Consult were searched for the terms diabetes mellitus and Urtica dioica without limitation up to 15th September 2010. All the animal studies with the outcome of change in blood glucose or other relevant complications of diabetes and all available abstracts were included. Review articles and letters to the editor were excluded. Search of databases resulted in 724 articles which 87 were potentially relevant studies on Urtica dioica and diabetes. On the basis of inclusion/exclusion criteria, 21 studies were finally included. One human and 20 animal studies were reviewed for the efficacy of Urtica dioica. Most of these studies showed significant decrease in blood glucose and complications of diabetes by use of Urtica dioica. Urtica dioica can affect both pancreatic and extra pancreatic pathways. Available evidences suggest that Urtica dioica can be used to treat diabetes and its long-term complications. Of course, further experiments would help determine exact mechanisms of action, effects and side effects of this herbal medicine. |
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