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Articles by Bagher Minaee
Total Records ( 2 ) for Bagher Minaee
  Sepideh Arbabi Bidgoli , Bagher Minaee , Mohammad H. Ghahremani , Mansoor Djamali Zavarei , Shamileh Fouladdel and Ebrahim Azizi
  The present study was carried out to determine the TP status in colorectal cancer and to correlate molecular alterations with sex and other clinicopathological findings. Out of 129 surgically resected colorectal cancer patients, 51 tumor samples (23 males, 28 females) were randomly analyzed by immunohistochemical techniques using primary antibody for TP and LSAB2 detection kit. Despite the lack of significant correlation between patients’ sex and most other clinicopathological parameters, the mean tumor size in males (5.7174±1.8453 cm) was significantly (p=0.016) more than females (4.4643±1.8453 cm) in this study. Out of 51 postoperative colorectal tumor samples, 24 (47.1%) showed positive TP expression. Unlike other clinicopathological parameters, TP immunostaining was significantly correlated with tumor size (p=0.007), lymphatic invasion (p= 0.036) and sex of patients (p=0.002). The prevalence of TP positive immunostaining was significantly higher in males than females (66.6% versus 33.3%, respectively). Due to the importance of high TP expression in predicting the tumor responses to fluoropyrimidines, the results of the present study possibly show the role of sex hormones in TP expression and angiogenesis. This finding might be important in being considered as a valuable prognostic or predictive marker in clinical settings.
  Sepideh Arbabi Bidgoli , Bagher Minaee , Mansoor Djamali Zavarehi , Shamileh Fouladdel and Ebrahim Azizi
  Comparative study of markers of drug resistance in cancer tissues may be extremely helpful in selection of effective chemotherapeutic regimen. P-glycoprotein (P-gp) and Topoisomerase II α (Topo II α) are two fundamental proteins in multi-drug resistance phenomenon (MDR). This study determined the expression and significance of P-gp and Topo II α proteins in advanced gastric carcinomas and correlated molecular alterations with clinicopathological findings. Tissue samples of 35 patients with advanced type gastric adenocarcinoma were analyzed. Immunohistochemical techniques were applied using primary antibodies for P-gp or Topo II α and LSAB2 detection kit (Dako-Denmark). Positive immunostaining for P-gp and Topo II α were observed in 42.9% and 17.2% of tumor samples, respectively. Negative expressions of P-gp and TopoII were associated with sex (p = 0.035 and 0.0001) and histological grade (p = 0.021 and 0.0001), respectively. Unlike P-gp, an inverse relationship between Topo II α expression and size of tumors (p = 0.012) and lymphatic invasion (p = 0.013) were observed. Considering the key role of positive P-gp or negative Topo II α expression in MDR, it could be concluded that groups of patients with P-gp over expression (42.9%) or lack of Topo II α expression (82.8%) would less likely benefit from available chemotherapeutic regimens. Therefore, we highly recommend determination of tumor status for expression of tumor markers such as P-gp and Topo II α, before deciding about effective chemotherapeutic regimen for patients with gastric cancer.
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