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Articles by Bader Mubarak Aljaeid
Total Records ( 3 ) for Bader Mubarak Aljaeid
  Bader Mubarak Aljaeid and Mohamed Ahmed El-Moselhy
  Background and Objective: Gentamicin sulphate (GN) is a broad-spectrum antibiotic used for treatment of several types of infection. However, it can cause vasoconstriction, leading to serious adverse effects, such as kidney damage and inner ear problems. The aim of this study was to suppress GN nephrotoxicity and to sustain its release. Methodology: Polycaprolactone (PCL) nanoparticles (NPs) were loaded with GN and alpha lipoic acid (ALA) using the solvent evaporation technique. The prepared NPs were assessed for particle size, zeta potential, morphology, entrapment efficiency percentage and GN release. Finally, an in vivo nephrotoxicity study was carried out to assess the protective effect of ALA on the kidneys of rabbits. Results: Data revealed that the prepared GN-ALA-PCL NPs were in the nano size range. GN was released more slowly than pure GN, thus sustaining its effect. Creatinine increased 1.4-fold in the pure GN group in comparison with the control group and other electrolytes (sodium, calcium and potassium) showed abnormal results for the pure GN group. There was no significant difference in creatinine and the other electrolytes between the GN-ALA-PCL NPs group and the control group. Data confirm the protective effect of ALA against GN nephrotoxicity. Conclusion: Loading of GN with ALA on PCL NPs could be a successful strategy to inhibit GN nephrotoxicity and extend GN release, which enhances its safety and dose frequency profiles.
  Usama Ahmed Fahmy and Bader Mubarak Aljaeid
  Background and Objective: Erectile dysfunction (ED) is a common condition, especially in diabetic males. Alpha-lipoic acid (ALA) can protect endothelial cells from oxidative stress damage. The purpose of this study was to find a new treatment for ED in diabetic patients via combined ALA with tadalafil (TFL) in a transdermal patch to enhance the skin permeability of TFL and protect epithelia cells lined penile vessels from the oxidative stress induced by hyperglycemia. Materials and Methods: A solubility study was carried out for TFL and ALA, followed by nine formulae with different ratios of oil, surfactant and co-surfactant. TFL released from the formulated patch was compared with a raw TFL patch and afterward, permeation of the formulated TFL was imaged. The difference between the treatments was estimated using one way-analysis of variance test. Results: Anise oil and Tween 20 showed highest solubility for both drugs, while polyethylene glycol (PEG 200) solubilized 0.49±0.1 and 7.8±1.2 mg mL–1 of TFL and ALA, respectively, Formula A4, achieved the lowest globular size (134.3±12.3 nm) according to ternary phase diagram. TFL released was enhanced significantly by about 2.83-fold in the transdermal patch in comparison with raw TFL after 12 h, images clearly confirm the efficacy of penetration of the formula within the skin layers. According to cell viability (EA. hy926) data to assess the role of ALA in improvement of resistance of endothelial cells to oxidative stress, ALA increased cell survival by about 1.3-fold. Conclusion: The combination of ALA and TFL in the form of a self-nano emulsion drug delivery system as a transdermal patch could be a successful strategy for treatment of ED in diabetic patients.
  Mohamed Fouad Radwan , Mohamed Ahmed El- Moselhy , Usama Ahmed Fahmy and Bader Mubarak Aljaeid
  Background and Objective: Erectile dysfunction (ED) is a common disease in diabetic patients. Alprostadil (Prostaglandin E1, PGE1) has shown higher success rates compared with phosphodiesterase type 5 inhibitors (PDE-5) in the treatment of ED. The combined formula of PGE1 with D-tocopheryl polyethylene glycol succinate (TPGS) was aimed to find a novel treatment for diabetic patients suffering from ED via protecting epithelial cells that lined penile vessels from the oxidative stress. Materials and Methods: PGE1-TPGS was prepared either with labrasol, polyethylene glycol 200 (PEG 200) or a mixture of labrasol and PEG 200, F1, F2 and F3 respectively. The prepared formulations were characterized for morphology and zeta potential and then were added to 1.5% of hydroxypropyl methyl cellulose solution to form topical hydrogel. Drug release study for all investigated formulations was conducted in comparison with raw-PGE1 and tested in endothelial cells (EA. hy926) under stress condition. Results: The obtained data revealed that PGE1-TPGS prepared with labrasol achieved the highest particle size while, PGE1-TPGS formula of PEG 200 and labrasol mixture showed the smallest particle size. Transmission electron microscope (TEM) images of the prepared formulations showed spherical shape micelles. Oxidative stress investigation showed a dramatic improvement in epithelial cell survival that attenuated the permeation enhancer’s cytotoxicity. F1, F2 and F3 treatments showed improved cell viability when compared with blank formulations. At concentration 10 μg mL–1, results showed that the investigated formulations improved cell viability from 9.13% (F1 blank), 7.55% (F2 blank) and 8.82% (F3 blank) to 90.52, 91.27 and 93.94% for F1, F2 and F3 formulations, respectively. Conclusion: The study revealed that combination of PGE1 with TPGS micelles formula loaded topical gel could be a successful strategy for the treatment of ED in diabetic patients.
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