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Pharmacokinetics studies were performed in healthy red Sokoto
goats using chloramphenicol 25 mg kg-1. Following the drug administration
intravenously and intramuscularly samples of plasma were obtained in the goats
at various time intervals. Measurable blood levels of the drug were obtained
in goats for 6 h after intravenous injection and for 9 h after intramuscular
administration. A mean plasma concentration of chloramphenicol (25.63±2.01 μg
mL-1) was obtained at 0.08 h (5 min) after the intravenous administration
of the drug while the peak plasma concentration of the drug following intramuscular
treatment was 9.64±0.74 μg
mL-1 after 0.25 h (30 min). The apparent volume of distribution
and the total body clearance of chloramphenicol from the Sokoto red goats were higher after intramuscular than intravenous administration. About 80%
of the drug administered intramuscularly reached the plasma. This result has
yielded baseline data for further investigation(s) of the drug.
