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Articles by B.O. Idonije
Total Records ( 2 ) for B.O. Idonije
  O.I. Iribhogbe , J.E. Emordi , E.O. Nwoke , B.O. Idonije and U. Akpamu
  The purpose of this present study is to determine the influence of varying combinations of antioxidant Vitamins on the hyper-hepatic state of pregnancy. To achieve this, seventy pregnant Wister albino rats weighing between 250-300 g were procured and grouped into 2 control groups treated with distilled water and vehicle- tween-80, respectively and three cohorts (I, II and III) with four sub-groups each (n = 5). Starting from the 7th day, group I received a varying dose combination of Vitamin A+C, group II Vitamin A+E and group III Vitamin C+E respectively for 11 days. Results of liver function assay revealed that supplementation with Vitamin A+C, A+E and C+E caused a significant reduction (p<0.05) in serum protein and a non-significant (p>0.05) alteration in serum albumin. Except for ALT where Vitamin A+E combination produced no significant alteration, serum AST (Aspartate transaminase) and ALP (Alanine transaminase) were significantly reduced (p<0.05) with antioxidant Vitamin combination therapy when compared with control. Antioxidant vitamin combination may be advantageous in pregnancy induced hyper- hepatic state. However, further study is needed in this respect.
  B.O. Idonije , E.O. Nwoke , O. Festus and O.M. Oluba
  Malaria has protean clinical manifestations and Acute Renal Failure (ARF) is one of its serious complications and could be life threatening. Information on kidney involvement in malaria in Africa is still scanty and Nigeria is no exception. Kidney function was assessed in 60 (28 males and 32 females) malaria positive patients (as test subjects) and 40 (16 males and 24 females) malaria negative individuals (as controls) using plasma creatinine, urea and uric acid as test indicators. Descriptive analysis of results obtained showed that plasma creatinine level was significantly (p<0.05) increased in both males and females malaria positive patients (tests) compared to their respective controls (malaria negative males and females, respectively). Female test subjects also had significantly higher plasma urea concentration compared to female controls. No significant change (p>0.05) was observed in plasma uric acid between female test subjects and female control subjects. Similarly, plasma urea and uric acid levels were not significantly altered in male test subjects compared to male control subjects. Males test subjects were observed to have higher plasma levels of the test parameters compared to female test subjects. Comparative study between male and female test subjects showed significantly higher concentrations in plasma creatinine and uric acid in male test subjects compared to female test subjects. From these results, it is concluded that renal impairment is a clinical feature of malaria in Ekpoma, South-South Nigeria.
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