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Articles by B.N. Enemchukwu
Total Records ( 3 ) for B.N. Enemchukwu
  N.A. Obasi , U.C. Okorie , B.N. Enemchukwu , S.S. Ogundapo and G. Otuchristian
  The numerous ethno-medicinal applications of Picralima nitida plants have called for a high thorough-put investigation of all the parts of the plant including the peel that is usually discarded in order to ensure maximum utilization of the plant. In this study, nutritional evaluation, phytochemical screening and antimicrobial effects of Picralima nitida peel were carried out using standard methods, in order to determine the potentials of this discarded part of the plant. The results of proximate contents indicated the following: moisture (49.6%), ash (16.0%), crude fibre (10.5%), crude lipid (7.4%), crude protein (28.4%) and carbohydrate (37.7%) while its calorific value is 265.8 kcal/100 g. Thus, the nutritional value of Picralima nitida peel is high and as such it could be used as feed additives. The results of phytochemical screening revealed the presence of flavonoids, saponins, tannins and alkaloids and the aqueous extract had antimicrobial activities against Escherichia coli and staphylococcus aureus with varying degrees. The most potent inhibitory effect was observed with Escherichia coli. These results have revealed that the peel and its extracts have pharmacological active compounds and antibacterial effects and as such could be used in ethno-medicine for the treatment of microbial infection and other ailments.
  B.N. Enemchukwu , C.C. Ibe , S.C. Udedi , A. Iroha , K.I. Ubaoji and S.S. Ogundapo
  Malaria and typhoid fever are among the most endemic diseases in the tropics and are associated with poverty and underdevelopment with significant morbidity and mortality. Both diseases can lead to liver damage if not properly treated. The liver function assessment was therefore conducted on (90) volunteer patients; comprising (30) patients with malaria only, (30) with typhoid only and (30) with malaria-typhoid co-infection randomly selected from Abia State University Teaching Hospital, Aba, Abia State, Nigeria and (20) healthy individuals were used as control. Blood samples collected from these subjects were screened for malaria parasite and Staphylococcus typhi using standard methods. Mean serum levels of ALP (112.55±84.23), AST (31.33±12.80), ALT (23.10±11.84), TB (19.43±5.02), CB (5.91±3.03) and ALP(116.69±48.68), AST (28.33±11.72), ALT (22.8±5.94), TB (19.31±5.84),CB (5.60±2.50) were obtained for those subjects with malaria and typhoid respectively and subjects with malaria-typhoid co-infection recorded the following; ALP (134.33±56.62), AST (33.97±8.43), ALT (24.40±4.37),TB (21.27±2.96),CB (6.58±3.10) while the control subjects had mean serum levels of ALP (71.05±18.18), AST (16.65±7.45), ALT (13.85±6.09),TB (10.05±4.85) and CB (3.00±1.67). These mean values were subjected to a statistical test using students t-test which revealed a significant increase (p<0.05).The results suggest that malaria, typhoid and malaria-typhoid co-infection can elevate ALP, AST, ALT,TB and CB serum levels and can lead to liver damage if not properly treated.
  A.J. Uraku , O.H. Uraku , S.C. Onuoha , N. Edwin , C. Ezeali , N.N. Ezeani , O.U. Obasi , N.V. Ogoh , E.J. Dingwoke , O.F. Orinya , F.N. Nweke , P.E. Ozioma and B.N. Enemchukwu
  Background and Objective: Lead is an environmental pollutant. The painful invasive chelation therapy makes it exigent to continue the protracted treatment against lead toxicity. This study is aimed at evaluating the protective effect of the methanol and flavonoid-rich leaf extracts of T. triangulae on lead-induced toxicity. Materials and Methods: Thirtysix male albino rats were used and were distributed into five groups; A, B, C D and E. Groups D and E were further subdivided into three; D1, D2, D3, E1, E2 and E3. Both groups and subgroups contained four rats each. All groups except A were intraperitoneally injected a single dose of 50 mg kg1 b.wt., of lead chloride and commenced treatment within 30 min of lead injection. Group A and B were given distilled water and 50 mg kg1 b.wt., of lead chloride only, respectively. Group C was treated only with 40 mg kg1 vitamin C while groups D1, D2, D3 and E1, E2, E3 were treated with 50, 100 and 200 mg kg1 b.wt., of methanol and flavonoid-rich leaf extract of T. triangulae, respectively for 14 days once daily. Blood were collected for determination of antioxidant indices in plasma using standard method and data were analyzed using SPSS version 20. Results: The result showed that methanol and flavonoid-rich extracts significantly (p<0.05) decrease the Malondialdehyde (MDA) level that was triggered by the increase oxidative stress when treated with lead. The levels of glutathione and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were increased significantly when treated with the extracts. Conclusion: The outcome of this study showed that the extracts have a protective effect on lead-induced toxicity.
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