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Articles by B.M. Agaie
Total Records ( 2 ) for B.M. Agaie
  E.U. Etuk , B.M. Agaie , P.A. Onyeyili and C.U. Ottah
  This study examines the effect of aqueous extract of Boswellia dalzielii stem bark on castor oil induced diarrhoea in albino rats. Graded doses of the extract (100, 200 and 300 mg kg-1) were administered orally to three groups of rats (n = 6) before induction of diarrhoea with castor oil. Another two groups of the animals were treated with normal saline (control) and diphenoxylate, a conventional anti-diarrhoea drug respectively. In a separate experiment, an isolated ileum of rabbit was mounted in an organ bath containing aerated Tyrode solution. The tissue was stimulated with acetylcholine (2 μg) and its responses recorded. Various concentrations of the extract (2, 5, 10 and 20 μg) were applied to the tissue and the responses recorded. The responses were similarly recorded when acetylcholine was separately combined with atropine and 10 μg of the extract. The extract produced a significant inhibition of the castor oil induced diarrhoea in the animals in a dose dependent manner. Furthermore, the extract relaxed isolated rabbit ileum and reduced the contractions induced by acetylcholine in a manner similar to atropine during the in vitro studies. These findings suggest that, aqueous stem bark extract of Boswellia dalzielii possesses anti-diarrhoea effect, which may be related to anticholinergic mechanisms.
  B.M. Agaie , P.A. Onyeyili , B.Y. Muhammad and M.J. Ladan
  Some toxic effects of the aqeous leaf extract of Anogeissus leiocarpus was evaluated in rats using changes in haematological and biochemical parameters as well as body weight changes. The results indicate that the extract had no significant effect (p>0.05) on haematological parameters except the packed cell volume and lymphocytes. Significant (p<0.05) dose-dependent increase were observed in serum levels of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase. Serum sodium and potassium were not affected by extract administration. However, total protein, bilirubin, urea and cholesterol as well as body weight values were significantly lower than in the control especially in groups that received higher doses. The results of this study therefore suggest that the leaf extract of this plant could affect feed intake and utilization and also elicit some changes in biochemical parameters of rats.
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