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Articles by B.H. Ridzwan
Total Records ( 3 ) for B.H. Ridzwan
  Abd El-Aziem Farouk , Faizal Abd. Hamid Ghouse and B.H. Ridzwan
  In this study, several Malaysian sea cucumber species that have traditional medicine value were selected and from them, the native bacterial population was isolated. Optimization of growth was designed and all bacterial secretions were tested for antibacterial properties. 30 bacterial types were isolated and 7 types recorded moderate antibacterial activity against K. pneumoniae, S. marscens, P. aeruginosa and E. feacalis. Antibacterial plate screening was done, with various testing parameters. Turbidometry revealed a single dose of the 10x concentrated crude antibacterial extracts were effective in preventing pathogenic growth for up to 4 hrs. PCR and subsequent sequencing of the 16S rDNA showed that the bacterial species were from the halopholic Bacillus and Klebsiella genera.
  B.H. Ridzwan , Y. Su Fong , M.H. Hasniwati , B. Shaari and K.C.A. Jalal
  The effects of Morinda citrifolia (Rubiceace) extract on coronary perfusion pressure, contractility and heart rate of isolated rats hearts were studied by using the technique of Langendorff system. Sodium nitroprusside (SNP) was used as a positive control and standard while saline was used as negative control. The extract at doses of 1.0 and 10 mg, respectively showed a significant decrease in coronary perfusion pressure compared with saline. The extract dose of 10 mg showed a maximum decrease in coronary perfusion pressure, developed tension and heart rate. The next part of the study was to investigate the involvement of nitric oxide in the coronary vasodilatory effects of the extract. The inhibitor of nitric oxide synthesis, NG-nitro-L-arginine metil ester (L-NAME) 300 μM was perfused together with Krebs-Henseleit solution in the heart for test group, while the time-matched control group without L-NAME. L-NAME did not abolish the decrease of coronary perfusion pressure and developed tension by the second injection. So, nitric oxide is not involved in the mechanism of coronary vasodilation. In conclusion, the M. citrifolia extract decreased coronary perfusion pressure and developed tension.
  B.H. Ridzwan , T.C. Leong and S.Z. Idid
  Sea cucumber or "gamat", as it is locally known is one of the traditional medicine that has been used until today. It is believed to help accelerate wound healing, especially after giving birth and also help to relief post-surgery pain. This experiment is to study the antinociceptive effect of water extract from sea cucumbers Holothuria leucospilota Brandt, Bohadschia marmorata vitiensis Jaeger and also the antinociceptive effect of coelomic fluid from Stichopus hermanii in mice. Two methods were used, i.e. writhing test and tail-flick test, in comparison to morphine sulphate and normal saline as positive and negative control, respectively. In the writhing test, the group of mice treated subcutaneously with control normal saline did not show a significant (p<0.05) inhibition effect. Mice group treated subcutaneously with extract and coelomic fluid of sea cucumbers (50, 75 and 100 mg kg -1) and also morphine sulphate (0.8 mg kg-1) were found to inhibit abdominal contraction induced by acetic acid (0.6%). The tail-flick test using water bath (50 ° C) showed a weak antinociceptive effect at the dose of 100 and 200 mg kg -1, but was not statistically significant (p<0.05). This effect could be seen 15 min after intraperitoneal administration of extracts or morphine sulphate (5 mg kg-1) into the mice. However, when tested statistically, both methods showed no dose-response relationship for the doses used. Hence, this study suggests the potential of water extract from H. leucospilota and B. marmorata vitiensis and the coelomic fluid from S. hermanii as alternative analgesic drug sources in the future.
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